Pharmacokinetics of an allergen and a monomeric allergoid for oromucosal immunotherapy in allergic volunteers

Little is known about the pharmacokinetics of allergens for local immunotherapy. Thus, we studied the pharmacokinetics in allergic volunteers of a commercial allergenic vaccine in orosoluble tablets (LAIS®, Lofarma S.p.A). The carbamylated monomeric allergoid derived from Parietaria judaica major al...

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Bibliographic Details
Published in:Clinical and experimental allergy 2001-01, Vol.31 (1), p.54-60
Main Authors: Bagnasco, M., Passalacqua, G., Villa, G., Augeri, C., Flamigni, G., Borini, E., Falagiani, P., Mistrello, G., Canonica, G.W., Mariani, G.
Format: Article
Language:English
Subjects:
Administration, Sublingual
Adult
Allergens - administration & dosage
Allergens - immunology
allergoid
Biological and medical sciences
Desensitization, Immunologic
Female
Glycoproteins - administration & dosage
Glycoproteins - immunology
Glycoproteins - pharmacokinetics
Humans
Immunopathology
Immunotherapy (general aspects)
Iodine Radioisotopes - blood
local immunotherapy
Male
Medical sciences
Par j 1
pharmacokinetics
Plant Extracts - administration & dosage
Plant Extracts - immunology
Plant Extracts - pharmacokinetics
Plant Proteins - administration & dosage
Plant Proteins - immunology
Plant Proteins - pharmacokinetics
radiolabelling
Radionuclide Imaging
Respiratory Hypersensitivity - therapy
Vaccines - immunology
Vaccines - pharmacokinetics
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Summary:Little is known about the pharmacokinetics of allergens for local immunotherapy. Thus, we studied the pharmacokinetics in allergic volunteers of a commercial allergenic vaccine in orosoluble tablets (LAIS®, Lofarma S.p.A). The carbamylated monomeric allergoid derived from Parietaria judaica major allergen (Par j 1), characterized by maintenance of the original molecular size, and the native allergen, were radiolabelled with 123I, then incorporated into the commercial soluble tablets and administered to allergic subjects. Early sequential and late static scintigraphic acquisitions were performed, and plasma radioactivity was measured at different time intervals. No difference in local pharmacokinetics was observed between the allergen and the allergoid: part of the tracer was retained in the mouth for at least 2 h after swallowing. No direct absorption through the oral mucosa could be detected, as plasma radioactivity increased only after swallowing and peaked at 2 h. However, the plasma peak attained with the allergoid in tablets was significantly higher with respect to the native allergen. Finally, some undegraded allergoid, but not the allergen, could be constantly detected in the bloodstream at plasma peak. The results showed a similar behaviour of the allergoid and the allergen in tablets as far as their local kinetics are concerned, whereas plasma peak was higher with the allergoid than with the allergen. Therefore we conclude that the chemical modification of the allergen may affect its pharmacokinetics, by making it less susceptible to enzymatic degradation.
ISSN:0954-7894
1365-2222
DOI:10.1046/j.1365-2222.2001.00999.x