Structures and functions of yeast kinetochore complexes

The kinetochore is a key cell division organelle that enables high-fidelity transmission of genetic information by coupling chromosomes to spindle microtubules during mitosis and meiosis. Despite its cytological description more than a century ago, remarkably little information is available on kinet...

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Bibliographic Details
Published in:Annual review of biochemistry 2007-01, Vol.76 (1), p.563-591
Main Authors: Westermann, Stefan, Drubin, David G, Barnes, Georjana
Format: Article
Language:English
Subjects:
Aurora Kinases
Biochemistry
Cell Cycle Proteins - chemistry
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cell Cycle Proteins - ultrastructure
Cell division
Centromere - metabolism
Chromosome Segregation
Chromosomes
Cytoskeletal Proteins - genetics
Cytoskeletal Proteins - metabolism
Intracellular Signaling Peptides and Proteins
Kinetochores - metabolism
Kinetochores - ultrastructure
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
Microtubule-Associated Proteins - ultrastructure
Microtubules - metabolism
Models, Molecular
Molecular Motor Proteins - metabolism
Multiprotein Complexes
Nuclear Proteins - chemistry
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Protein Kinases - genetics
Protein Kinases - metabolism
Protein-Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - chemistry
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
Saccharomyces cerevisiae Proteins - ultrastructure
Yeast
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Summary:The kinetochore is a key cell division organelle that enables high-fidelity transmission of genetic information by coupling chromosomes to spindle microtubules during mitosis and meiosis. Despite its cytological description more than a century ago, remarkably little information is available on kinetochore function at a molecular level. Recently, important advances elucidating the overall organization of kinetochores, as well as information about the structures and molecular mechanisms of kinetochore function, have been achieved through a detailed analysis of the kinetochores of the budding yeast Saccharomyces cerevisiae. Here we review the current understanding of kinetochore function in budding yeast and draw comparisons to recent findings in other organisms.
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.biochem.76.052705.160607