Postpartum Tuberculosis Incidence and Mortality among HIV-Infected Women and Their Infants in Pune, India, 2002–2005

Background. In contrast with many other countries, isoniazid preventative therapy is not recommended in clinical care guidelines for human immunodeficiency virus (HIV)—infected persons with latent tuberculosis (TB) in India. Methods. Seven hundred fifteen HIV-infected mothers and their infants were...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-07, Vol.45 (2), p.241-249
Main Authors: Gupta, Amita, Nayak, Uma, Ram, Malathi, Bhosale, Ramesh, Patil, Sandesh, Basavraj, Anita, Kakrani, Arjun, Philip, Sheeja, Desai, Dipali, Sastry, Jayagowri, Bollinger, Robert C.
Format: Article
Language:English
Subjects:
Age Distribution
AIDS
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - drug therapy
AIDS-Related Opportunistic Infections - epidemiology
Antitubercular Agents - therapeutic use
Babies
Death
Drug therapy
Female
Hemoglobins
HIV
HIV/AIDS
Human immunodeficiency virus
Humans
Incidence
India - epidemiology
Infant
Infant, Newborn
Infants
Infectious Disease Transmission, Vertical - prevention & control
Infectious Disease Transmission, Vertical - statistics & numerical data
Mortality
Mothers
Mycobacterium tuberculosis
Nevirapine - administration & dosage
Postpartum Period
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Trimester, Third
Prospective Studies
Regression analysis
Risk Assessment
Sex Distribution
Survival Analysis
Tuberculin
Tuberculosis
Tuberculosis - diagnosis
Tuberculosis - drug therapy
Tuberculosis - epidemiology
Tuberculosis - transmission
Urban Population
Women
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Summary:Background. In contrast with many other countries, isoniazid preventative therapy is not recommended in clinical care guidelines for human immunodeficiency virus (HIV)—infected persons with latent tuberculosis (TB) in India. Methods. Seven hundred fifteen HIV-infected mothers and their infants were prospectively followed up for 1 year after delivery at a public hospital in Pune, India. Women were evaluated for active TB during regular clinic visits, and tuberculin skin tests were performed. World Health Organization definitions for confirmed, probable, and presumed TB were used. Poisson regression was performed to determine correlates of incident TB, and adjusted probabilities of mortality were calculated. Results. Twenty-four of 715 HIV-infected women who were followed up for 480 postpartum person-years developed TB, yielding a TB incidence of 5.0 cases per 100 person-years (95% confidence interval [CI], 3.2–7.4 cases per 100 person-years). Predictors of incident TB included a baseline CD4 cell count
ISSN:1058-4838
1537-6591
DOI:10.1086/518974