Altered E-cadherin/β-catenin expression in oral squamous carcinoma with and without nodal metastasis

Objectives:  The aim of this study was to investigate the potential use of E‐cadherin, a tumour‐suppressor gene product involved in establishing cell–cell adhesion and one of its associated proteins, β‐catenin, as markers of nodal metastasis in oral squamous cell carcinoma (OSCC). Materials and meth...

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Bibliographic Details
Published in:Oral diseases 2007-07, Vol.13 (4), p.386-392
Main Authors: Mahomed, F, Altini, M, Meer, S
Format: Article
Language:English
Subjects:
Adult
Aged
beta Catenin - analysis
Biomarkers, Tumor - analysis
Cadherins - analysis
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Cell Adhesion - genetics
Cell Differentiation - genetics
Dentistry
E-cadherin
Female
Gene Expression Regulation, Neoplastic - genetics
Humans
Immunohistochemistry
invasive tumour front
Lymphatic Metastasis - pathology
Male
metastasis
Middle Aged
Mouth Mucosa - pathology
Mouth Neoplasms - pathology
Neoplasm Invasiveness
oral cancer
β-catenin
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Summary:Objectives:  The aim of this study was to investigate the potential use of E‐cadherin, a tumour‐suppressor gene product involved in establishing cell–cell adhesion and one of its associated proteins, β‐catenin, as markers of nodal metastasis in oral squamous cell carcinoma (OSCC). Materials and methods:  Thirty invasive OSCCs in patients with (n = 19) and without (n = 11) nodal metastases, as confirmed on histopathologic examination of the resected regional lymph nodes (n = 30), were examined for E‐cadherin and β‐catenin expression by immunohistochemistry. Results:  There was a highly significant association (P 
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2006.01295.x