Chemical sensors and biosensors in liquid environment based on microcantilevers with amplified quality factor

A new technique is presented for bio/chemical sensors, based on microcantilevers, for detection in liquid environment. The low quality factor of the cantilever in liquid is increased up to three orders of magnitude by using Q-control. This enables AC detection that is immune to the long-term drift o...

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Bibliographic Details
Published in:Ultramicroscopy 2001, Vol.86 (1), p.167-173
Main Authors: Tamayo, J, Humphris, A.D.L, Malloy, A.M, Miles, M.J
Format: Article
Language:English
Subjects:
Antibodies - metabolism
Antigens - analysis
Antigens - metabolism
Atomic force microscopes
Atomic force microscopy
Biological and medical sciences
Biological techniques and instrumentation
biomedical engineering
Biosensing Techniques
Biosensor
Chemical sensor
Chemistry Techniques, Analytical - methods
Ethanol - analysis
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General aspects
General equipment and techniques
Humans
Instrumentation. Materials. Reagents. Research laboratory organization
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Microscopy, Atomic Force - instrumentation
Microscopy, Atomic Force - methods
Physics
Polymethyl Methacrylate - chemistry
Scanning probe microscopes, components and techniques
Sensors (chemical, optical, electrical, movement, gas, etc.)
remote sensing
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Summary:A new technique is presented for bio/chemical sensors, based on microcantilevers, for detection in liquid environment. The low quality factor of the cantilever in liquid is increased up to three orders of magnitude by using Q-control. This enables AC detection that is immune to the long-term drift of the DC cantilever response in liquids, and to temperature variations. This technique has been applied for the detection of ethanol in aqueous solution by using the microbalance method, and for antibody/antigen recognition by the surface stress method. The results show the feasibility and very high sensitivity of these novel devices.
ISSN:0304-3991
1879-2723
DOI:10.1016/S0304-3991(00)00082-6