Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function

Although the syndrome of heart failure with preserved systolic function may occur in up to 40% of all heart failure patients, the clinical, angiographic characteristics, and long-term outcomes of these patients are poorly understood. We prospectively evaluated 2,498 consecutive patients with New Yor...

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Bibliographic Details
Published in:The American journal of cardiology 2000-10, Vol.86 (8), p.863-867
Main Authors: O’Connor, Christopher M, Gattis, Wendy A, Shaw, Linda, Cuffe, Michael S, Califf, Robert M
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Clinical outcomes
Comorbidity
Coronary Angiography
Female
Heart
Heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Male
Medical sciences
Middle Aged
Mortality
Proportional Hazards Models
Surgery
Survival Analysis
Systole - physiology
Treatment Outcome
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Summary:Although the syndrome of heart failure with preserved systolic function may occur in up to 40% of all heart failure patients, the clinical, angiographic characteristics, and long-term outcomes of these patients are poorly understood. We prospectively evaluated 2,498 consecutive patients with New York Heart Association class II to IV symptoms and ejection fractions of >40%, who underwent cardiac catheterization between January 1984 and December 1996 at Duke University Medical Center. The median age for the entire cohort was 63 years; 25% of the population was >71 years old. In addition, 55% of the patients were women, 65% had ischemic heart disease, 28% had a history of diabetes, and 62% had a history of hypertension. The median ejection fraction was 58%. One third of the patients had multivessel disease by coronary angiography. The overall 5-year mortality of the total population was 28%. The independent predictors of mortality (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01107-3