Role of novel markers of inflammation in patients with stable coronary heart disease

The role of novel markers of inflammation in patients with coronary heart disease (CHD) is still unclear. We conducted a case-control study to assess the association between various markers of inflammation and the presence and severity of chronic stable CHD. We included 312 clinically stable patient...

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Bibliographic Details
Published in:The American journal of cardiology 2001-02, Vol.87 (3), p.262-266
Main Authors: Hoffmeister, Albrecht, Rothenbacher, Dietrich, Bäzner, Ute, Fröhlich, Margit, Brenner, Hermann, Hombach, Vinzenz, Koenig, Wolfgang
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - immunology
Coronary heart disease
Female
Health risk assessment
Heart
Humans
Inflammation Mediators - blood
Male
Medical sciences
Medical screening
Middle Aged
Prognosis
Risk Factors
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Summary:The role of novel markers of inflammation in patients with coronary heart disease (CHD) is still unclear. We conducted a case-control study to assess the association between various markers of inflammation and the presence and severity of chronic stable CHD. We included 312 clinically stable patients with angiographically documented CHD, aged 40 to 68 years. Voluntary blood donors (n = 479) matched for age and gender served as controls. High-sensitivity C-reactive protein, serum amyloid A, plasminogen activator inhibitor-1 activity, von Willebrand factor, fibrinogen, plasma viscosity, albumin, and neutrophils were determined. The severity of CHD was evaluated by 3 coronary scoring systems: the clinical 1- to 3-vessel disease score, the American Heart Association extension score (1 to 15 segments), and the Gensini score. All markers of inflammation were highly significantly elevated (all p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01355-2