Effects of exercise rehabilitation on endothelial reactivity in older patients with peripheral arterial disease

Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelial function, which is a measure of vascular health, is impaired in patients with PAD. We examined the effects of 6 months of aerobic exercise rehabilitation on brachial artery endothelial function, assessed using...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2001-02, Vol.87 (3), p.324-329
Main Authors: Brendle, David C, Joseph, Lyndon J.O, Corretti, Mary C, Gardner, Andrew W, Katzel, Leslie I
Format: Article
Language:English
Subjects:
Aged
Arterial Occlusive Diseases - physiopathology
Arterial Occlusive Diseases - rehabilitation
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical outcomes
Coronary vessels
Disease
Endothelium, Vascular - physiopathology
Exercise
Exercise - physiology
Female
Follow-Up Studies
Humans
Intermittent Claudication - physiopathology
Intermittent Claudication - rehabilitation
Ischemia - physiopathology
Ischemia - rehabilitation
Leg - blood supply
Male
Medical sciences
Older people
Rehabilitation
Treatment Outcome
Vascular Resistance - physiology
Vasodilation - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Peripheral arterial disease (PAD) is a major cause of morbidity and mortality. Endothelial function, which is a measure of vascular health, is impaired in patients with PAD. We examined the effects of 6 months of aerobic exercise rehabilitation on brachial artery endothelial function, assessed using high-frequency ultrasonography, and calf blood flow in 19 older PAD patients (age 69 ± 1 years, mean ± SEM) with intermittent claudication (ankle to brachial artery index of 0.73 ± 0.04). After exercise, the time to onset of claudication pain increased by 94%, from 271 ± 49 to 525 ± 80 seconds (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)01367-9