Liver Fibrosis Progression Is Related to CD4 Cell Depletion in Patients Coinfected with Hepatitis C Virus and Human Immunodeficiency Virus

A total of 204 patients with liver biopsy—proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean a...

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Bibliographic Details
Published in:The Journal of infectious diseases 2001-01, Vol.183 (1), p.134-137
Main Authors: Puoti, Massimo, Bonacini, Maurizio, Spinetti, Angiola, Putzolu, Valeria, Govindarajan, Sugantha, Zaltron, Serena, Favret, Maurizio, Callea, Francesco, Gargiulo, Francesco, Donato, Francesco, Carosi, Giampiero
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsies
CD4 antigen
CD4 Lymphocyte Count
Cirrhosis
Cohort Studies
Coinfection
Concise Communication
Disease Progression
Female
Fibrosis
Genotypes
hepatitis C virus
Hepatitis C, Chronic - complications
HIV
HIV Infections - complications
HIV Infections - immunology
HIV Seropositivity - complications
HIV Seropositivity - immunology
human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Liver
Liver Cirrhosis - epidemiology
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Male
Medical sciences
Odds Ratio
Risk Factors
RNA
T lymphocytes
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:A total of 204 patients with liver biopsy—proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts
ISSN:0022-1899
1537-6613
DOI:10.1086/317644