Association of HLA-DRB116 with chronic discoid lupus erythematosus in Mexican mestizo patients

Summary Background.  Chronic discoid lupus erythematosus (CDLE) is present in 15–30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease. Aim.  The aim of this study was to determine gene frequencies of HLA‐DRB1 alleles i...

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Bibliographic Details
Published in:Clinical and experimental dermatology 2007-07, Vol.32 (4), p.435-438
Main Authors: López-Tello, A., Rodríguez-Carreón, A.A., Jurado, F., Yamamoto-Furusho, J. K., Castillo-Vázquez, M., Chávez-Muñoz, C., Salgado, N., Arellano-Campos, O., Vargas-Alarcón, G., Granados, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Biological and medical sciences
Child
Chronic Disease
Dermatology
Female
Gene Frequency
Genes, MHC Class II
Genetic Predisposition to Disease - genetics
HLA-DR Antigens - genetics
HLA-DR Serological Subtypes
HLA-DRB1 Chains
Humans
Lupus Erythematosus, Discoid - genetics
Male
Medical sciences
Mexico - ethnology
Middle Aged
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Summary Background.  Chronic discoid lupus erythematosus (CDLE) is present in 15–30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease. Aim.  The aim of this study was to determine gene frequencies of HLA‐DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease. Methods.  The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA‐DRB1 and DQ allele typing was performed by sequence‐specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls. Results.  In the patient group, a significantly increased gene frequency was found for the HLA‐DR4 (P = 0.016, OR = 2.24, 95% CI 1.14–4.38) and HLA‐DR16 alleles (P = 0.005, OR = 5.51, 95% CI 1.49–21.08). Conclusion.  HLA‐DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.2007.02391.x