FGF21: A Missing Link in the Biology of Fasting

A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism ( Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circ...

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Bibliographic Details
Published in:Cell metabolism 2007-06, Vol.5 (6), p.405-407
Main Author: Reitman, Marc L.
Format: Article
Language:English
Subjects:
Fasting - physiology
Fibroblast Growth Factors - physiology
Humans
Liver - cytology
Liver - metabolism
PPAR alpha - physiology
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Summary:A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism ( Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARα transcription factor, is a “missing link” in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2007.05.010