Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors

Propionibacterium acnes plays an important role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles. Recently, it was suggested that P. acnes cells residing within the follicles grow as a biofilm. In the present study, we tested the biofilm-forming ability of sever...

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Bibliographic Details
Published in:Research in microbiology 2007-05, Vol.158 (4), p.386-392
Main Authors: Coenye, Tom, Peeters, Elke, Nelis, Hans J.
Format: Article
Language:English
Subjects:
Acne vulgaris
Acne Vulgaris - microbiology
Amino Acid Sequence
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biofilm
Biofilms - drug effects
Biofilms - growth & development
Biological and medical sciences
Carbon-Sulfur Lyases - chemistry
Carbon-Sulfur Lyases - genetics
Carbon-Sulfur Lyases - metabolism
Drug Resistance, Bacterial
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Bacterial
Homoserine - analogs & derivatives
Homoserine - genetics
Homoserine - metabolism
Humans
Lactones - metabolism
Lipase
Lipase - genetics
Lipase - metabolism
Microbial Sensitivity Tests - methods
Microbiology
Molecular Sequence Data
Propionibacterium acnes
Propionibacterium acnes - drug effects
Propionibacterium acnes - growth & development
Quorum Sensing
Virulence Factors - genetics
Virulence Factors - metabolism
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Summary:Propionibacterium acnes plays an important role in the pathogenesis of acne vulgaris, a common disorder of the pilosebaceous follicles. Recently, it was suggested that P. acnes cells residing within the follicles grow as a biofilm. In the present study, we tested the biofilm-forming ability of several P. acnes strains in a microtiter plate model. We also evaluated the resistance of biofilm-grown P. acnes towards antimicrobial agents commonly used in the treatment of acne and the production of putative virulence factors. Our results indicate that P. acnes can form biofilms in vitro. The results also show that sessile P. acnes cells are more resistant to various commonly used antimicrobial agents than planktonic cells. In addition, sessile cells produce more extracellular lipases as well as significant amounts of the quorum-sensing molecule autoinducer-2.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2007.02.001