Adrenergic enhancement of consolidation of object recognition memory

Extensive evidence indicates that epinephrine (EPI) modulates memory consolidation for emotionally arousing tasks in animals and human subjects. However, previous studies have not examined the effects of EPI on consolidation of recognition memory. Here we report that systemic administration of EPI e...

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Bibliographic Details
Published in:Neurobiology of learning and memory 2007-07, Vol.88 (1), p.137-142
Main Authors: Dornelles, Arethuza, de Lima, Maria Noemia Martins, Grazziotin, Manoela, Presti-Torres, Juliana, Garcia, Vanessa Athaide, Scalco, Felipe Siciliani, Roesler, Rafael, Schröder, Nadja
Format: Article
Language:English
Subjects:
Adrenoceptors
Analysis of Variance
Animals
Antagonist drugs
Arousal - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain research
Epinephrine
Epinephrine - physiology
Fundamental and applied biological sciences. Psychology
Male
Memory
Memory consolidation
Neurology
Neurotransmitters
Pattern Recognition, Visual - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Receptors, Adrenergic, beta - physiology
Recognition (Psychology) - physiology
Recognition memory
Retention (Psychology) - physiology
Rodents
Statistics, Nonparametric
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Summary:Extensive evidence indicates that epinephrine (EPI) modulates memory consolidation for emotionally arousing tasks in animals and human subjects. However, previous studies have not examined the effects of EPI on consolidation of recognition memory. Here we report that systemic administration of EPI enhances consolidation of memory for a novel object recognition (NOR) task under different training conditions. Control male rats given a systemic injection of saline (0.9% NaCl) immediately after NOR training showed significant memory retention when tested at 1.5 or 24, but not 96 h after training. In contrast, rats given a post-training injection of EPI showed significant retention of NOR at all delays. In a second experiment using a different training condition, rats treated with EPI, but not SAL-treated animals, showed significant NOR retention at both 1.5 and 24-h delays. We next showed that the EPI-induced enhancement of retention tested at 96 h after training was prevented by pretraining systemic administration of the β-adrenoceptor antagonist propranolol. The findings suggest that, as previously observed in experiments using aversively motivated tasks, epinephrine modulates consolidation of recognition memory and that the effects require activation of β-adrenoceptors.
ISSN:1074-7427
1095-9564
DOI:10.1016/j.nlm.2007.01.005