Melanotic schwannoma

Abstract Background Melanotic schwannomas are tumors of Schwann cell origin, characterized by cytoplasmic deposition of melanin. Melanotic schwannomas are rare. Description of the course of these tumors differs somewhat, but it is generally considered a benign lesion. Clinical presentation A 54-year...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2007-07, Vol.14 (7), p.676-678
Main Authors: Er, Uygur, Kazanci, Atilla, Eyriparmak, Taner, Yigitkanli, Kazim, Senveli, Engin
Format: Article
Language:English
Subjects:
Humans
Intradural extramedullary tumor
Male
Malignant melanoma
Melanoma - pathology
Melanoma - surgery
Melanotic schwannoma
Middle Aged
Neurilemmoma - pathology
Neurilemmoma - surgery
Neurology
S100 Proteins - metabolism
Spinal Cord Neoplasms - pathology
Spinal Cord Neoplasms - surgery
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Summary:Abstract Background Melanotic schwannomas are tumors of Schwann cell origin, characterized by cytoplasmic deposition of melanin. Melanotic schwannomas are rare. Description of the course of these tumors differs somewhat, but it is generally considered a benign lesion. Clinical presentation A 54-year-old man presented with hypoesthesia, pain and weakness of the right arm and leg for 4 months. An MRI scan revealed an intradural extramedullary lesion at the level of the foramen magnum and C1. Operation Total resection of the mass was performed. A diagnosis of melanotic schwannoma was made based on histologic morphology and the immunohistochemical profile. Over a 2-year follow-up period there has been no local recurrence. Conclusion Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features of Schwann cells. Distinguishing between this tumor and malignant melanoma is important in planning management. Total resection should be performed. Appropriate long-term follow-up is needed for all melanotic schwannomas.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2006.03.010