Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea

A chemical investigation of the marine sponge Phyllospongia papyracea, collected in Papua New Guinea, initiated by the screening result of a β-catenin/Tcf4 disruption assay afforded six new bishomoscalarane sesterterpenes containing two rare scalaranes with a cyclobutane ring in the molecule, togeth...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-05, Vol.70 (5), p.802-807
Main Authors: Li, Hou-Jin, Amagata, Taro, Tenney, Karen, Crews, Phillip
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
beta Catenin - drug effects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Humans
Marine Biology
Molecular Structure
Other biological molecules
Papua New Guinea
Phyllospongia papyracea
Porifera - chemistry
Sesterterpenes
TCF Transcription Factors - drug effects
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - pharmacology
Terpenes, steroids. Hormones
Transcription Factor 7-Like 2 Protein
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Summary:A chemical investigation of the marine sponge Phyllospongia papyracea, collected in Papua New Guinea, initiated by the screening result of a β-catenin/Tcf4 disruption assay afforded six new bishomoscalarane sesterterpenes containing two rare scalaranes with a cyclobutane ring in the molecule, together with one known scalarane sesterterpene. The structures of the new compounds were elucidated by 1D and 2D spectroscopic techniques. The compounds isolated in this study did not show activity against the β-catenin and Tcf4 complex.
ISSN:0163-3864
1520-6025
DOI:10.1021/np070020f