Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete resp...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of immunology (1950) 2001-01, Vol.166 (1), p.15-19
Main Authors: Hajjar, Adeline M, O'Mahony, D. Shane, Ozinsky, Adrian, Underhill, David M, Aderem, Alan, Klebanoff, Seymour J, Wilson, Christopher B
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - antagonists & inhibitors
Bacterial Proteins - physiology
Bacterial Toxins - antagonists & inhibitors
Bacterial Toxins - metabolism
Cell Line
Cloning, Molecular
Drosophila Proteins
Extracellular Space - immunology
Humans
Membrane Glycoproteins - antagonists & inhibitors
Membrane Glycoproteins - genetics
Membrane Glycoproteins - metabolism
Membrane Glycoproteins - physiology
Mice
Mice, Inbred C3H
Molecular Sequence Data
Phenols
Protein Structure, Tertiary - genetics
Protein Structure, Tertiary - physiology
Receptors, Cell Surface - antagonists & inhibitors
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Receptors, Cell Surface - physiology
Solubility
Staphylococcus epidermidis - immunology
Toll-Like Receptor 1
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptor 6
Toll-Like Receptors
Transfection
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete response to LPSs. We report here that TLR2 transduces the response to phenol-soluble modulin, a factor secreted by Staphylococcus epidermidis. The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors. We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.166.1.15