Preoperative serum levels of c-erbB-2 do not seem to be useful in management of patients with rectal cancer

Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial. The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostic...

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Bibliographic Details
Published in:International journal of colorectal disease 2007-07, Vol.22 (7), p.827-831
Main Authors: KOVACEVIC, Dujo, SONICKI, Zdenko, KUSIC, Zvonko, BOLANCA, Ante, GRUBISIC, Goran, LUKAC, Maja, LUKAC, Josip
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - blood
Adenocarcinoma - mortality
Adenocarcinoma - surgery
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - blood
Breast cancer
Carcinoembryonic Antigen - blood
Colectomy
Colorectal cancer
Colorectal carcinoma
Diagnosis
Enzyme-Linked Immunosorbent Assay
ErbB protein
ErbB-2 protein
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Gynecology. Andrology. Obstetrics
Humans
Male
Mammary gland diseases
Medical sciences
Metastases
Metastasis
Middle Aged
Patients
Preoperative Care
Prognosis
Receptor, ErbB-2 - blood
Rectal Neoplasms - blood
Rectal Neoplasms - surgery
Rectum
Serum levels
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Survival
Survival Rate
Time Factors
Tumors
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Summary:Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial. The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients. Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery. Preoperative serum c-erbB-2 levels were significantly higher in stage IV patients than in healthy controls (P
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-006-0200-z