Trends in the incidence and treatment of parathyroid cancer in the United States

BACKGROUND. Parathyroid cancer is a rare cause of hyperparathyroidism. The objectives of this study were to determine the patterns of disease, treatment trends, and outcomes among patients with parathyroid cancer by using a population‐based data source. METHODS. Surveillance, Epidemiology, and End R...

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Published in:Cancer 2007-05, Vol.109 (9), p.1736-1741
Main Authors: Lee, Peter K., Jarosek, Stephanie L., Virnig, Beth A., Evasovich, Maria, Tuttle, Todd M.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Biological and medical sciences
Endocrinopathies
Female
Humans
hyperparathyroidism
Incidence
Male
Malignant tumors
Medical sciences
Middle Aged
parathyroid cancer
Parathyroid Neoplasms - epidemiology
Parathyroid Neoplasms - pathology
Parathyroid Neoplasms - therapy
parathyroidectomy
Parathyroidectomy - trends
Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases)
SEER Program
Sex Factors
Survival Rate
Treatment Outcome
trends
Tumors
United States
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Summary:BACKGROUND. Parathyroid cancer is a rare cause of hyperparathyroidism. The objectives of this study were to determine the patterns of disease, treatment trends, and outcomes among patients with parathyroid cancer by using a population‐based data source. METHODS. Surveillance, Epidemiology, and End Results (SEER) cancer registry data were used to identify patients who were diagnosed with parathyroid cancer from 1988 through 2003. To assess whether the incidence rate, treatment, tumor size, and cancer stage changed over time, the Cochrane‐Armitage trend test was used, and Cox proportional‐hazards modeling was used to identify the factors associated with an improved overall survival rate. RESULTS. From 1988 through 2003, 224 patients with parathyroid cancer were reported in the SEER data. Over that 16‐year study period, the incidence of parathyroid cancer increased by 60% (1988–1991, 3.58 per 10,000,000 population; 2000–2003, 5.73 per 10,000,000 population). Most patients (96%) underwent surgery (parathyroidectomy, 78.6% of patients; en bloc resection, 12.5% of patients; other, 4.9% of patients). The rate of surgical treatment increased significantly during the study period. The 10‐year all‐cause mortality rate was 33.2%, and the 10‐year cancer‐related mortality rate was 12.4%. Patient age (P < .0001), sex (P = .0106), the presence of distant metastases at diagnosis (P = .0004), and the year of diagnosis (P = .0287) were associated significantly with the overall survival rate. Tumor size, lymph node status, and type of surgery were not associated significantly with the overall survival rate. CONCLUSIONS. Although parathyroid cancer is rare, the incidence increased significantly in the United States from 1988 through 2003. Young age, female gender, recent year of diagnosis, and absence of distant metastases were associated significantly with an improved survival rate. Cancer 2007. © 2007 American Cancer Society. The incidence of parathyroid cancer was very low, but it significantly increased in the United States from 1988 to 2003. The rate of surgical treatment also increased.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.22599