Purification by ozonolysis of (18)O enriched water after cyclotron irradiation and the utilization of the purified water for the production of [18F]-FDG (2-deoxy-2-[18F]-fluoro-d-glucose)

The high cost of virgin (18)O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [(18)O]H(2)O was purified by ozonolysis and distillation. Analyses showed a large decre...

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Bibliographic Details
Published in:	Applied radiation and isotopes 2007-07, Vol.65 (7), p.831-835
Main Authors:	Asti, M, Grassi, E, Sghedoni, R, De Pietri, G, Fioroni, F, Versari, A, Borasi, G, Salvo, D
Format:	Article
Language:	eng
Subjects:	Cyclotrons Fluorodeoxyglucose F18 - chemistry Oxygen Isotopes - chemistry Radiopharmaceuticals - chemistry Water - chemistry
Online Access:	Get full text
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Summary:	The high cost of virgin (18)O-enriched water has forced many researchers to study methods to purify and recycle enriched water after the first irradiation for the production of radiopharmaceuticals. In our study, [(18)O]H(2)O was purified by ozonolysis and distillation. Analyses showed a large decrease in impurities after this treatment. The purification procedure was carried out after the production of 94 batches of [18F]-FDG, which were manufactured using a GE Minitrace cyclotron and a GE Mx TracerLab synthesizer. Saturation yields after bombardment, using virgin and re-purified water were, respectively, 2864+/-204MBq/muA and 2727+/-167MBq/muA, a decrease of 5.5%. The decrease in [18F]-FDG yield, from 67.2+/-0.7% to 65.5+/-0.9%, can be ascribed to the irradiation step only.
ISSN:	0969-8043 1872-9800