Suicide prevention: disruption of apoptotic pathways by protozoan parasites

The modulation of apoptosis has emerged as an important weapon in the pathogenic arsenal of multiple intracellular protozoan parasites. Cryptosporidium parvum, Leishmania spp., Trypanosoma cruzi, Theileria spp., Toxoplasma gondii and Plasmodium spp. have all been shown to inhibit the apoptotic respo...

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Bibliographic Details
Published in:Molecular microbiology 2007-05, Vol.64 (4), p.904-916
Main Authors: Carmen, John C, Sinai, Anthony P
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biological and medical sciences
Cryptosporidium parvum
Eukaryota - cytology
Eukaryota - immunology
Eukaryota - metabolism
Fundamental and applied biological sciences. Psychology
Leishmania
Life cycles
Microbiology
Parasitic protozoa
Pathology
Plasmodium
Protozoan Infections - parasitology
Signal Transduction
Theileria
Toxoplasma gondii
Trypanosoma cruzi
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Summary:The modulation of apoptosis has emerged as an important weapon in the pathogenic arsenal of multiple intracellular protozoan parasites. Cryptosporidium parvum, Leishmania spp., Trypanosoma cruzi, Theileria spp., Toxoplasma gondii and Plasmodium spp. have all been shown to inhibit the apoptotic response of their host cell. While the pathogen mediators responsible for this modulation are unknown, the parasites are interacting with multiple apoptotic regulatory systems to render their host cell refractory to apoptosis during critical phases of intracellular infection, including parasite invasion, establishment and replication. Additionally, emerging evidence suggests that the parasite life cycle stage impacts the modulation of apoptosis and possibly parasite differentiation. Dissection of the host-pathogen interactions involved in modulating apoptosis reveals a dynamic and complex interaction that recent studies are beginning to unravel.
ISSN:0950-382X
1365-2958
DOI:10.1111/j.1365-2958.2007.05714.x