Plasma Concentrations of Myeloperoxidase Predict Mortality After Myocardial Infarction

Plasma Concentrations of Myeloperoxidase Predict Mortality After Myocardial Infarction Tessa J. Mocatta, Anna P. Pilbrow, Vicky A. Cameron, Revathy Senthilmohan, Chris M. Frampton, A. Mark Richards, Christine C. Winterbourn Plasma levels of myeloperoxidase (MPO) and protein oxidation markers were in...

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Published in:Journal of the American College of Cardiology 2007-05, Vol.49 (20), p.1993-2000
Main Authors: Mocatta, Tessa J., MSc, Pilbrow, Anna P., PhD, Cameron, Vicky A., PhD, Senthilmohan, Revathy, PhD, Frampton, Chris M., PhD, Richards, A. Mark, MD, PhD, Winterbourn, Christine C., PhD
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Angioplasty
Biomarkers - blood
Cardiology
Cardiovascular
Cardiovascular disease
Case-Control Studies
Diabetes Mellitus, Type 2 - complications
Female
Follow-Up Studies
Heart attacks
Humans
Internal Medicine
Male
Middle Aged
Mortality
Myocardial Infarction - blood
Myocardial Infarction - mortality
Neurotransmitter Agents - blood
New Zealand - epidemiology
Peroxidase - blood
Plasma
Prognosis
Proportional Hazards Models
Protein Carbonylation
Radionuclide Imaging
Retrospective Studies
Sex Factors
Stroke Volume
Tyrosine - analogs & derivatives
Tyrosine - blood
Ventricular Dysfunction, Left - diagnostic imaging
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Summary:Plasma Concentrations of Myeloperoxidase Predict Mortality After Myocardial Infarction Tessa J. Mocatta, Anna P. Pilbrow, Vicky A. Cameron, Revathy Senthilmohan, Chris M. Frampton, A. Mark Richards, Christine C. Winterbourn Plasma levels of myeloperoxidase (MPO) and protein oxidation markers were investigated in relation to mortality in patients with acute myocardial infarction (MI) (n = 512). The MPO and protein carbonyls were elevated after MI. 3-Chlorotyrosine was not elevated in any patients, implying that hypochlorous acid produced by MPO was unlikely to be responsible for the increased protein carbonyls. Above-median levels of MPO were independently associated with increased 5-year mortality (risk ratio = 1.8, 95% confidence interval 1.0 to 3.0, p = 0.034). Patients with above-median MPO levels in combination with above-median levels of plasma N-terminal fragment of brain naturetic peptide or below-median left ventricular ejection fraction had significantly greater mortality compared with other patients.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.02.040