Charting plant interactomes: possibilities and challenges

Protein–protein interactions are essential for nearly all cellular processes. Therefore, an important goal of post-genomic research for defining gene function and understanding the function of macromolecular complexes involves creating ‘interactome’ maps from empirical or inferred datasets. Systemat...

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Bibliographic Details
Published in:	Trends in plant science 2008-04, Vol.13 (4), p.183-191
Main Authors:	Morsy, Mustafa, Gouthu, Satyanarayana, Orchard, Sandra, Thorneycroft, David, Harper, Jeff F., Mittler, Ron, Cushman, John C.
Format:	Article
Language:	eng
Subjects:	Biological and medical sciences Biotechnology Computational Biology - methods Databases, Protein Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics literature reviews Methods. Procedures. Technologies Models, Biological plant biochemistry plant proteins Plant Proteins - genetics Plant Proteins - metabolism Protein Binding Protein Interaction Mapping - methods protein-protein interactions Transgenic animals and transgenic plants Transgenic plants
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Summary:	Protein–protein interactions are essential for nearly all cellular processes. Therefore, an important goal of post-genomic research for defining gene function and understanding the function of macromolecular complexes involves creating ‘interactome’ maps from empirical or inferred datasets. Systematic efforts to conduct high-throughput surveys of protein–protein interactions in plants are needed to chart the complex and dynamic interaction networks that occur throughout plant development. However, no single approach can build a complete map of the interactome. Here, we review the utility and potential of various experimental approaches for creating large-scale protein–protein interaction maps in plants. Bioinformatics approaches for curating and assessing the confidence of these datasets through inter-species comparisons will be crucial in achieving a complete understanding of protein interaction networks in plants.
ISSN:	1360-1385 1878-4372