Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications

In this study, a series of hydrogels was synthesized by free radical polymerization, namely poly(2‐(hydroxyethyl)methacrylate) (pHEMA), poly(4‐(hydroxybutyl)methacrylate) (pHBMA), poly(6‐(hydroxyhexyl)methacrylate) (pHHMA), and copolymers composed of N‐isopropylacrylamide (NIPAA), methacrylic acid (...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2008-05, Vol.85B (2), p.417-426
Main Authors: Jones, David S., Lorimer, Colin P., McCoy, Colin P., Gorman, Sean P.
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - chemistry
Anti-Infective Agents, Local - pharmacology
antimicrobial
bioactive material
Chlorhexidine - chemistry
Chlorhexidine - pharmacology
Coated Materials, Biocompatible - chemical synthesis
Coated Materials, Biocompatible - chemistry
Delayed-Action Preparations - chemical synthesis
Delayed-Action Preparations - chemistry
drug delivery/release
Hot Temperature
hydrogel
Hydrogels - chemical synthesis
Hydrogels - chemistry
Materials Testing - methods
polymer
Polymethacrylic Acids - chemical synthesis
Polymethacrylic Acids - chemistry
Streptococcus - growth & development
Surface Properties
Time Factors
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Summary:In this study, a series of hydrogels was synthesized by free radical polymerization, namely poly(2‐(hydroxyethyl)methacrylate) (pHEMA), poly(4‐(hydroxybutyl)methacrylate) (pHBMA), poly(6‐(hydroxyhexyl)methacrylate) (pHHMA), and copolymers composed of N‐isopropylacrylamide (NIPAA), methacrylic acid (MA), NIPAA, and the above monomers. The surface, mechanical, and swelling properties (at 20 and 37°C, pH 6) of the polymers were determined using dynamic contact angle analysis, tensile analysis, and thermogravimetry, respectively. The Tg and lower critical solution temperatures (LCST) were determined using modulated DSC and oscillatory rheometry, respectively. Drug loading of the hydrogels with chlorhexidine diacetate was performed by immersion in a drug solution at 20°C (
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.30960