Urine fetuin‐A values in relation to the presence of urolithiasis

OBJECTIVE To investigate the relationship of urine fetuin‐A and other promotors and inhibitors of urine crystalization with urolithiasis, as fetuin‐A inhibits the precipitation of hydroxyapatite from supersaturated solutions of calcium and phosphate in vitro but no information on urine fetuin‐A in p...

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Published in:BJU international 2008-05, Vol.101 (9), p.1151-1154
Main Authors: Stejskal, David, Karpisek, Michal, Vrtal, Radovan, Student, Vladimir, Solichova, Pavlina, Fiala, Richard, Stejskal, Pavel
Format: Article
Language:English
Subjects:
alpha-Fetoproteins - metabolism
alpha-Fetoproteins - urine
Biological and medical sciences
Case-Control Studies
Crystallization
ELISA
Enzyme-Linked Immunosorbent Assay
Female
fetuin‐A (AHSG)
Humans
kidney
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Recurrence
Sensitivity and Specificity
Urinary lithiasis
urolithiasis
Urolithiasis - blood
Urolithiasis - pathology
Urolithiasis - urine
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Summary:OBJECTIVE To investigate the relationship of urine fetuin‐A and other promotors and inhibitors of urine crystalization with urolithiasis, as fetuin‐A inhibits the precipitation of hydroxyapatite from supersaturated solutions of calcium and phosphate in vitro but no information on urine fetuin‐A in patients with urolithiasis is available. PATIENTS AND METHODS In all, 39 patients with urolithiasis and 22 individuals with no urolithiasis or probands with undetected stones were involved. All patients underwent kidney ultrasonography and X‐ray examination, and body mass index (BMI) was calculated. Serum creatinine, parathyroid hormone, calcium, magnesium, anorganic phosphate, uric acid and urine creatinine, albumin, α1‐microglobulin, sulphate, oxalate, citrate and fetuin‐A (ELISA) were determined. RESULTS The patients with urolithiasis had lower urine fetuin‐A levels (median 4.9 vs 0.77 mg/day; P 
ISSN:1464-4096
1464-410X
DOI:10.1111/j.1464-410X.2007.07432.x