Successful treatment of disseminated Geotrichum capitatum infection with a combination of caspofungin and voriconazole in an immunocompromised patient

Disseminated Geotrichum capitatum infection is uncommon, and has been reported exclusively in immunocompromised patients. The prognosis is poor with a mortality rate of approximately 50-75%. We report a case of disseminated G. capitatum infection in a severely neutropenic patient who was receiving c...

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Bibliographic Details
Published in:Mycoses 2008-05, Vol.51 (3), p.270-272
Main Authors: Etienne, A, Datry, A, Gaspar, N, Morel, V, Delabesse, E, Lmimouni, B, Vernant, J.P, Dhédin, N
Format: Article
Language:eng ; ger
Subjects:
Antifungal Agents - therapeutic use
Drug Combinations
Echinocandins - therapeutic use
Geotrichosis - diagnosis
Geotrichosis - drug therapy
Geotrichosis - immunology
Geotrichum - isolation & purification
Geotrichum capitatum
Humans
Immunocompromised Host
Lipopeptides
Male
Middle Aged
Pyrimidines - therapeutic use
Triazoles - therapeutic use
Voriconazole
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Summary:Disseminated Geotrichum capitatum infection is uncommon, and has been reported exclusively in immunocompromised patients. The prognosis is poor with a mortality rate of approximately 50-75%. We report a case of disseminated G. capitatum infection in a severely neutropenic patient who was receiving chemotherapy for acute myeloblastic leukaemia. G. capitatum was isolated from blood cultures, skin lesions, bronchoalveolar lavage fluid, throat swabs and stools. The infection was successfully cured with a combination of voriconazole and caspofungin.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2007.01484.x