Leishmania manipulates sandfly feeding to enhance its transmission

Malaria parasites manipulate mosquitoes to ensure transmission between mammalian hosts; painstaking experiments have now demonstrated that another medically important protozoan, Leishmania , enhances its transmission through the adaptive manipulation of one of its sandfly vectors, Lutzomyia longipal...

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Bibliographic Details
Published in:Trends in parasitology 2008-04, Vol.24 (4), p.151-153
Main Author: Ready, Paul D
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Biological and medical sciences
Disease Models, Animal
Feeding Behavior - physiology
Female
Gastroenterology and Hepatology
Host-Parasite Interactions - physiology
Human protozoal diseases
Infectious Disease
Infectious diseases
Insect Vectors - parasitology
Leishmania
Leishmania - metabolism
Leishmania - pathogenicity
Leishmaniasis - metabolism
Leishmaniasis - transmission
Leshmaniasis
Lutzomyia longipalpis
Medical sciences
Membrane Proteins - metabolism
Mice
Mice, Inbred BALB C
Parasitic diseases
Parasitic Diseases, Animal - parasitology
Proteoglycans - metabolism
Protozoal diseases
Protozoan Proteins - metabolism
Psychodidae - parasitology
Psychodidae - physiology
Rodent Diseases - parasitology
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Summary:Malaria parasites manipulate mosquitoes to ensure transmission between mammalian hosts; painstaking experiments have now demonstrated that another medically important protozoan, Leishmania , enhances its transmission through the adaptive manipulation of one of its sandfly vectors, Lutzomyia longipalpis . Experimental Leishmania infections specifically increased sandfly biting persistence and feeding on multiple hosts, but only if the parasites produced infective forms and a gel plug of filamentous proteophosphoglycan in the anterior midgut of the sandfly. This fundamental research is relevant to vaccine development.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2007.12.007