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Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes
Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein of the Ras family which probably has a regulatory function. We demonstrate that Rasd1 mRNA is expressed in mouse lymph node cells in response to inhibitory stimuli. Rasd1 mRNA is present at very low levels in freshly isolated cells, bu...
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| Published in: | International immunology 2007-05, Vol.19 (5), p.583-590 |
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| Language: | English |
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| container_title | International immunology |
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| creator | Lindsey, JW |
| description | Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein of the Ras family which probably has a regulatory function. We demonstrate that Rasd1 mRNA is expressed in mouse lymph node cells in response to inhibitory stimuli. Rasd1 mRNA is present at very low levels in freshly isolated cells, but it is rapidly up-regulated in culture and is expressed at elevated levels in cells whose proliferation is blocked by exposure to homogenized brain tissue. The cells expressing Rasd1 mRNA are positive for MHC class II and B220 and negative for Thy-1. Expression of Rasd1 mRNA is very low in B cell-deficient mice. We conclude that Rasd1 mRNA is expressed by B lymphocytes derived from lymph node cells in response to inactivating or inhibitory stimuli. It may play a role in regulating B lymphocyte activity and proliferation. |
| doi_str_mv | 10.1093/intimm/dxm023 |
| format | article |
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We demonstrate that Rasd1 mRNA is expressed in mouse lymph node cells in response to inhibitory stimuli. Rasd1 mRNA is present at very low levels in freshly isolated cells, but it is rapidly up-regulated in culture and is expressed at elevated levels in cells whose proliferation is blocked by exposure to homogenized brain tissue. The cells expressing Rasd1 mRNA are positive for MHC class II and B220 and negative for Thy-1. Expression of Rasd1 mRNA is very low in B cell-deficient mice. We conclude that Rasd1 mRNA is expressed by B lymphocytes derived from lymph node cells in response to inactivating or inhibitory stimuli. It may play a role in regulating B lymphocyte activity and proliferation.</description><identifier>ISSN: 0953-8178</identifier><identifier>EISSN: 1460-2377</identifier><identifier>DOI: 10.1093/intimm/dxm023</identifier><identifier>PMID: 17369188</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Animals ; B cells ; B-Lymphocytes - cytology ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; Cell Proliferation - drug effects ; Cells, Cultured ; Dexamethasone - pharmacology ; Female ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - immunology ; Genes, ras - drug effects ; Histocompatibility Antigens Class II - immunology ; immune regulation ; Lymph Nodes - immunology ; Lymphocyte Activation - drug effects ; Lymphocyte Activation - immunology ; Mice ; Ras proteins ; ras Proteins - biosynthesis ; ras Proteins - drug effects ; ras Proteins - immunology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - isolation & purification ; Thy-1 Antigens - immunology</subject><ispartof>International immunology, 2007-05, Vol.19 (5), p.583-590</ispartof><rights>The Japanese Society for Immunology. 2007. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>The Japanese Society for Immunology. 2007. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-9879339048b9350167ea44a752739226e61232aef9e102d9827ac8e32e31a3503</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,1591,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17369188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindsey, JW</creatorcontrib><title>Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes</title><title>International immunology</title><addtitle>Int Immunol</addtitle><description>Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein of the Ras family which probably has a regulatory function. We demonstrate that Rasd1 mRNA is expressed in mouse lymph node cells in response to inhibitory stimuli. Rasd1 mRNA is present at very low levels in freshly isolated cells, but it is rapidly up-regulated in culture and is expressed at elevated levels in cells whose proliferation is blocked by exposure to homogenized brain tissue. The cells expressing Rasd1 mRNA are positive for MHC class II and B220 and negative for Thy-1. Expression of Rasd1 mRNA is very low in B cell-deficient mice. We conclude that Rasd1 mRNA is expressed by B lymphocytes derived from lymph node cells in response to inactivating or inhibitory stimuli. It may play a role in regulating B lymphocyte activity and proliferation.</description><subject>Animals</subject><subject>B cells</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Dexamethasone - pharmacology</subject><subject>Female</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - immunology</subject><subject>Genes, ras - drug effects</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>immune regulation</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Activation - immunology</subject><subject>Mice</subject><subject>Ras proteins</subject><subject>ras Proteins - biosynthesis</subject><subject>ras Proteins - drug effects</subject><subject>ras Proteins - immunology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - isolation & purification</subject><subject>Thy-1 Antigens - immunology</subject><issn>0953-8178</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqF0UlLxDAUB_Agio7L0asUD-KlmuS1WY6O44oiioJ4MMT2jVa7mbQw8-2NdFDwIiQkgV_-L-ERss3oAaMaDou6K6rqMJ9VlMMSGbFE0JiDlMtkRHUKsWJSrZF1798ppcA1rJI1JkFoptSIPE9wZivs3qxvaoyLOu8zzKM762OHpe3CvnVNh0UdsajwkY3acAo1bRk5fO0Dadz8x4Qxjsp51b412bxDv0lWprb0uLVYN8jD6cn98Xl8dXN2cXx0FWcp412sldQAmibqRUNKmZBok8TKlEvQnAsUjAO3ONXIKM-14tJmCoEjMBsuwAbZG3LDQz579J2pCp9hWdoam94bSRORaK7-hUwLEeZ34u4f-N70rg6fCCalVGqZBBQPKHON9w6npnVFZd3cMGq-22OG9pihPcHvLEL7lwrzX73oRwD7A2j69t-sRe3Cdzj7wdZ9GCFBpub88cmo8e3kcjK5Ngq-ALk7qPY</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Lindsey, JW</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes</title><author>Lindsey, JW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-9879339048b9350167ea44a752739226e61232aef9e102d9827ac8e32e31a3503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>B cells</topic><topic>B-Lymphocytes - 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Academic</collection><jtitle>International immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindsey, JW</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes</atitle><jtitle>International immunology</jtitle><addtitle>Int Immunol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>19</volume><issue>5</issue><spage>583</spage><epage>590</epage><pages>583-590</pages><issn>0953-8178</issn><eissn>1460-2377</eissn><notes>Transmitting editor: L. Steinman</notes><notes>istex:6599105D8B79035C59BE0F27D2D8DD18A5A5794E</notes><notes>ark:/67375/HXZ-8BQDJDDM-8</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein of the Ras family which probably has a regulatory function. We demonstrate that Rasd1 mRNA is expressed in mouse lymph node cells in response to inhibitory stimuli. Rasd1 mRNA is present at very low levels in freshly isolated cells, but it is rapidly up-regulated in culture and is expressed at elevated levels in cells whose proliferation is blocked by exposure to homogenized brain tissue. The cells expressing Rasd1 mRNA are positive for MHC class II and B220 and negative for Thy-1. Expression of Rasd1 mRNA is very low in B cell-deficient mice. We conclude that Rasd1 mRNA is expressed by B lymphocytes derived from lymph node cells in response to inactivating or inhibitory stimuli. It may play a role in regulating B lymphocyte activity and proliferation.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>17369188</pmid><doi>10.1093/intimm/dxm023</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International immunology, 2007-05, Vol.19 (5), p.583-590 |
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| language | eng |
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| source | Oxford Journals Online |
| subjects | Animals B cells B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Cell Proliferation - drug effects Cells, Cultured Dexamethasone - pharmacology Female Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Genes, ras - drug effects Histocompatibility Antigens Class II - immunology immune regulation Lymph Nodes - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mice Ras proteins ras Proteins - biosynthesis ras Proteins - drug effects ras Proteins - immunology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - isolation & purification Thy-1 Antigens - immunology |
| title | Dexamethasone-induced Ras-related protein 1 is a potential regulatory protein in B lymphocytes |
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