Preoperative Serum Vascular Endothelial Growth Factor-C (VEGF-C) Levels Predict Recurrence in Patients with Esophageal Cancer

Background: Circulating vascular endothelial growth factor-C (VEGF-C) levels were measured in patients with esophageal cancer to assess the value of VEGF-C as a biomarker for predicting tumor recurrence. Patients and Methods: Preoperative serum samples were acquired from 80 patients and healthy volu...

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Published in:Anticancer research 2008-01, Vol.28 (1A), p.165-169
Main Authors: KIMURA, Hitoshi, KATO, Hiroyuki, MANDA, Ryokuhei, FUKUCHI, Minoru, OJIMA, Hitoshi, TSUKADA, Katsuhiko, KUWANO, Hiroyuki, TANAKA, Naritaka, INOSE, Takanori, FARIED, Ahmad, SOHDA, Makoto, NAKAJIMA, Masanobu, FUKAI, Yasuyuki, MIYAZAKI, Tatsuya, MASUDA, Norihiro
Format: Article
Language:English
Subjects:
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Esophageal Neoplasms - blood
Esophageal Neoplasms - blood supply
Esophageal Neoplasms - pathology
Esophageal Neoplasms - surgery
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - pathology
Predictive Value of Tests
Preoperative Care
Sensitivity and Specificity
Tumors
Vascular Endothelial Growth Factor C - blood
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Summary:Background: Circulating vascular endothelial growth factor-C (VEGF-C) levels were measured in patients with esophageal cancer to assess the value of VEGF-C as a biomarker for predicting tumor recurrence. Patients and Methods: Preoperative serum samples were acquired from 80 patients and healthy volunteers who served as normal controls. VEGF-C levels were assessed using enzyme-linked immunosorbent assay (ELISA). Results: The preoperative serum VEGF-C level in patients with esophageal cancer was significantly higher than in healthy volunteers. Furthermore, patients with recurrence had significantly higher preoperative serum VEGF-C levels than patients without recurrence, and a high preoperative serum VEGF-C level was found to be an independent risk factor for recurrence, in addition to lymph node metastasis. Conclusion: Preoperative VEGF-C levels may reflect malignancy, such as lymph node metastasis, and predict recurrence in patients with esophageal cancer. Therefore, the preoperative VEGF-C level may be a useful biomarker for choice of multimodality therapy.
ISSN:0250-7005
1791-7530