Imidazo[1,2- a]pyridines with potent activity against herpesviruses

Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2- a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-05, Vol.17 (10), p.2735-2739
Main Authors: Gudmundsson, Kristjan S., Johns, Brian A.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiherpetic
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Biological and medical sciences
Herpesviridae - drug effects
HSV
Imidazo[1,2- a]pyridine
Imidazoles - chemistry
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Pyridines - chemistry
Pyrimidines - chemical synthesis
Pyrimidines - pharmacology
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Summary:Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2- a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2- a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2007.02.079