Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis

Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis Judith C. Sluimer, Jean-Marie Gasc, Job L. van Wanroij, Natasja Kisters, Mathijs Groeneweg, Maarten D. Sollewijn Gelpke, Jack P. Cleutjens, Luc H. van den Ak...

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Published in:Journal of the American College of Cardiology 2008-04, Vol.51 (13), p.1258-1265
Main Authors: Sluimer, Judith C., MSc, Gasc, Jean-Marie, PhD, van Wanroij, Job L., MD, Kisters, Natasja, BSc, Groeneweg, Mathijs, MSc, Sollewijn Gelpke, Maarten D., MSc, Cleutjens, Jack P., PhD, van den Akker, Luc H., MD, Corvol, Pierre, MD, PhD, Wouters, Bradly G., PhD, Daemen, Mat J., MD, PhD, Bijnens, Ann-Pascale J., PhD
Format: Article
Language:English
Subjects:
Aged
Angiogenesis
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Atherosclerosis
Biomarkers
Blood clots
Cardiology
Cardiovascular
Carotid Stenosis - physiopathology
Cross-Sectional Studies
Derivatives
Disease Progression
Endarterectomy, Carotid
Female
Humans
Hypoxia
Hypoxia - physiopathology
Hypoxia-Inducible Factor 1 - metabolism
Immunohistochemistry
Internal Medicine
Macrophages
Male
Middle Aged
Neovascularization, Pathologic
Nitroimidazoles
Oxidative Stress
Proteins
RNA, Messenger
Rodents
Studies
Transcription factors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
Veins & arteries
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Summary:Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis Judith C. Sluimer, Jean-Marie Gasc, Job L. van Wanroij, Natasja Kisters, Mathijs Groeneweg, Maarten D. Sollewijn Gelpke, Jack P. Cleutjens, Luc H. van den Akker, Pierre Corvol, Bradly G. Wouters, Mat J. Daemen, Ann-Pascale J. Bijnens Hypoxia was directly demonstrated in advanced atherosclerotic lesions of symptomatic patients with the use of pimonidazole administration before carotid endarterectomy. Hypoxia correlated with the presence of macrophages, angiogenesis, and a thrombus, and the expression of hypoxia-inducible transcription factor (HIF) and vascular endothelial growth factor. Also, the HIF pathway and microvessel density were associated with lesion progression and angiogenesis, suggesting the involvement of the HIF pathway in the response to hypoxia and the regulation of human intraplaque angiogenesis.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2007.12.025