Tumor necrosis factor-alpha gene promoter polymorphism in patients with familial Mediterranean fever

The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays an important role on the course of disease in familial Mediterranean fever (FMF). TNF-alpha gene promoter polymorphism may be a marker of susceptibility and severity of FMF. The aim of this study is to evaluate both TNF-alpha...

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Bibliographic Details
Published in:Clinical rheumatology 2007-06, Vol.26 (6), p.908-910
Main Authors: Celebi Kobak, Arzu, Kobak, Senol, Kabasakal, Yasemin, Akarca, Ulus Salih
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Familial Mediterranean fever
Familial Mediterranean Fever - genetics
Familial Mediterranean Fever - immunology
Female
Gene frequency
Gene polymorphism
Genes
Genotype
Humans
Inflammation
Male
Middle Aged
Polymorphism, Single Nucleotide - genetics
Promoter Regions, Genetic - genetics
Risk factors
Tumor Necrosis Factor-alpha - genetics
Tumor necrosis factor-α
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Summary:The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) plays an important role on the course of disease in familial Mediterranean fever (FMF). TNF-alpha gene promoter polymorphism may be a marker of susceptibility and severity of FMF. The aim of this study is to evaluate both TNF-alpha/238 and TNF-alpha/308 genotypes and allelic distribution in patients with FMF. Forty-one FMF patients and 43 healthy volunteers were included in the study. Genomic DNA was extracted from EDTA-preserved whole blood of whole series of patients and controls. Polymorphism of TNF-alpha promoter at positions -238 and -308 were detected by using amplification refractory mutation system polymerase chain reaction. TNF-alpha/238 and TNF-alpha/308 genotype distributions and allele frequencies of FMF patients and healthy volunteers were found to be similar. Moreover, there was no association between TNF-alpha/238 and TNF-alpha/308 genotypes and the frequency of acute attacks in FMF. TNF-alpha/238 and TNF-alpha/308 promoter polymorphisms do not seem to be major genetic risk factors for susceptibility to FMF and severity of the disease.
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-006-0430-z