Higher serum uric acid is associated with increased arterial stiffness in Japanese individuals

Abstract Hyperuricemia is postulated to be a risk factor for atherosclerotic diseases, although whether it is independent of classical atherogenic risk factors is controversial. The automatic computer-assisted measurement of brachial-ankle pulse wave velocity (baPWV) is a valid and reproducible meth...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 2007-05, Vol.192 (1), p.131-137
Main Authors: Ishizaka, Nobukazu, Ishizaka, Yuko, Toda, Ei-Ichi, Hashimoto, Hideki, Nagai, Ryozo, Yamakado, Minoru
Format: Article
Language:English
Subjects:
Aged
Aortic stiffness
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - blood
Biological and medical sciences
Blood and lymphatic vessels
Blood coagulation. Blood cells
Brachial Artery - diagnostic imaging
Brachial Artery - physiology
Cardiology. Vascular system
Cardiovascular
Carotid Arteries - diagnostic imaging
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - ethnology
Coronary heart disease
Elasticity
Female
Fundamental and applied biological sciences. Psychology
Heart
Humans
Hyperuricemia
Japan
Male
Mass Screening
Medical sciences
Metabolic syndrome
Metabolic Syndrome - blood
Middle Aged
Molecular and cellular biology
Multivariate analysis
Odds Ratio
Platelet
Pulsatile Flow - physiology
Pulse wave velocity
Risk Factors
Sex Factors
Ultrasonography
Uric Acid - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Hyperuricemia is postulated to be a risk factor for atherosclerotic diseases, although whether it is independent of classical atherogenic risk factors is controversial. The automatic computer-assisted measurement of brachial-ankle pulse wave velocity (baPWV) is a valid and reproducible method by which to assess arterial stiffness, a potential surrogate marker of early atherosclerosis. By analyzing cross-sectional data from 982 individuals who underwent health screening, we have investigated whether serum uric acid is associated with high baPWV, which was determined as the highest quartile of baPWV values, in a sex-specific manner. Multivariate analysis showed that the odds ratios (95% CI) of the highest baPWV quartile across the sex-specific quartiles of serum uric acid were 1.0, 2.80 (0.93–8.40), 2.13 (0.74–6.19), and 2.76 (1.01–7.55) in women, and 1.0, 1.10 (0.55–2.20), 1.97 (1.04–3.75), and 2.24 (1.10–4.56) in men after adjusting for age, total and HDL-cholesterol, BMI, systolic blood pressure, triglycerides, fasting glucose and smoking status. The association between uric acid and high baPWV was observed in both subjects with metabolic syndrome and those without. These data suggest that in both genders, serum uric acid level is associated with increased baPWV, a marker of arterial stiffness, and is in part independent of other conventional risk factors for atherosclerosis and metabolic syndrome.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2006.04.016