Novel methods for preparing phospholipid coated microbubbles

Two new methods for preparing phospholipid coated microbubble suspensions are elucidated. Firstly, co-axial electrohydrodynamic atomisation was utilized to generate 3–7 µm diameter microbubbles. Secondly, a specially designed and constructed T-junction device was used to prepare monodisperse microbu...

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Bibliographic Details
Published in:European biophysics journal 2008-04, Vol.37 (4), p.515-520
Main Authors: Pancholi, K. P., Farook, U., Moaleji, R., Stride, E., Edirisinghe, M. J.
Format: Article
Language:English
Subjects:
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedical engineering
Biophysics
Biophysics - methods
Biophysics Letter
Biotechnology
Cell Biology
Contrast Media
Drug delivery systems
Electrochemistry - methods
Equipment Design
Life Sciences
Lipids
Membrane Biology
Microbubbles
Nanotechnology
Neurobiology
Optics and Photonics
Particle Size
Phospholipids - chemistry
Sonication
Ultrasonics
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Summary:Two new methods for preparing phospholipid coated microbubble suspensions are elucidated. Firstly, co-axial electrohydrodynamic atomisation was utilized to generate 3–7 µm diameter microbubbles. Secondly, a specially designed and constructed T-junction device was used to prepare monodisperse microbubbles. Characteristics of microbubbles prepared by these two methods are compared with those obtained by sonication of the phospholipid suspension.
ISSN:0175-7571
1432-1017
DOI:10.1007/s00249-007-0211-x