Emergency Surgery of the Abdominal Aorta in a Porcine Model: Two Sequential Experiments

The aim of this study was to design an aggressive nonlethal animal model that would simulate surgical treatment of the abdominal aorta with a view to studying the systemic inflammatory response. Fourteen pigs were subjected to two sequential experiments. Experiment A was performed to determine the r...

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Bibliographic Details
Published in:World journal of surgery 2008-04, Vol.32 (4), p.642-647
Main Authors: Lozano, Francisco S., Rodríguez, José M., García-Criado, Francisco J., Gonzalez-Porras, Jose R., Sanchez-Guijo, Fermin M., Sanchez-Conde, Pilar, García-Sanchez, Jose E.
Format: Article
Language:English
Subjects:
Abdominal Aorta
Abdominal Surgery
Anastomosis, Surgical - adverse effects
Anastomosis, Surgical - methods
Anastomosis, Surgical - mortality
Animals
Aorta, Abdominal - surgery
Aortic Bypass
Biological and medical sciences
Blood Vessel Prosthesis Implantation - methods
Cardiac Surgery
Dissection
Emergencies
General aspects
General Surgery
Hemodynamics - physiology
Hemorrhage - complications
Hemorrhage - mortality
Lumbar Artery
Male
Medical sciences
Medicine
Medicine & Public Health
Models, Animal
Paraplegia
Surgery
Swine
Thoracic Surgery
Total Blood Volume
Treatment Outcome
Vascular Surgery
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Summary:The aim of this study was to design an aggressive nonlethal animal model that would simulate surgical treatment of the abdominal aorta with a view to studying the systemic inflammatory response. Fourteen pigs were subjected to two sequential experiments. Experiment A was performed to determine the response to two degrees of hemorrhage: (A1) 40% bleeding; and (A2) 60% bleeding over 15 minutes followed by midline laparotomy and aortic dissection. Experiment B included two methods of aortic repair: (B1) aortic resection and replacement with a prosthesis; and (B2) aortic bypass without aortic resection. In the latter two groups, suprarenal aortic cross-clamping was placed for 30 minutes after a 40% hemorrhage. We analyzed various inflammatory markers and mortality. The 40% bleeding (vs. 60%) elicited a smaller decrease in mean arterial pressure (110 ± 6 vs. 89 ± 9 mmHg) but did not cause irreversible shock or mortality. After the 40% hemorrhage, the B1 aortic repair caused two cases of paraplegia. We have developed a model to study the combined effect of bleeding and aortic cross-clamping.
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-007-9346-2