Disease activity as a major risk factor for osteonecrosis in early systemic lupus erythematosus

This study Identifies the possible risk factors for osteonecrosis (ON) in a homogenous group of early system lupus erythematosus (SLE). Forty-six consecutive SLE patients ( 0.05). Remarkably, the frequency of patients with system lupus erythematosus disease activity index (SLEDAI) ≥8 in the previous...

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Published in:Lupus 2007-01, Vol.16 (4), p.239-244
Main Authors: Fialho, S.C.M.S., Bonfá, E., Vitule, L.F., D'Amico, E., Caparbo, V., Gualandro, S., Pereira, R.M.R.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - therapeutic use
Bone marrow
Cohort Studies
Female
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Low density lipoprotein
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - pathology
Magnetic Resonance Imaging
Necrosis
Osteonecrosis - diagnosis
Osteonecrosis - etiology
Raynaud disease
Rheumatology
Risk Factors
Severity of Illness Index
Steroids
Triglycerides
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Summary:This study Identifies the possible risk factors for osteonecrosis (ON) in a homogenous group of early system lupus erythematosus (SLE). Forty-six consecutive SLE patients ( 0.05). Remarkably, the frequency of patients with system lupus erythematosus disease activity index (SLEDAI) ≥8 in the previous year of osteonecrosis clinical diagnosis was significantly higher when compared to patients without this manifestation (60.0% versus 19.4%, P = 0.011), supported by the higher glucocorticoid cumulative dose in the same period (P = 0.045). In contrast, these two parameters evaluated in 13th—24th months preceding osteonecrosis diagnosis were similar in patients with and without osteonecrosis (P > 0.05). In the logistic regression analysis only SLEDAI remained as an independent risk factor for ON (OR = 6.78, CI = 1.05—43.55, P = 0.04). Disease activity in the previous year of ON clinical diagnosis is the main predictor factor for the development of this complication in early SLE. Lupus (2007) 16, 239—244.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203307076771