Structure-Function Relationships of the NCKX2 Na+/Ca2+-K+ Exchanger

:  K+‐dependent Na+/Ca2+ exchangers (NCKX) have been shown to play important roles in physiological processes as diverse as phototransduction in rod photoreceptors, motor learning and memory in mice, and skin pigmentation in humans. Most structure–function studies on NCKX proteins have been carried...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2007-03, Vol.1099 (1), p.16-28
Main Authors: SHIBUKAWA, Y., KANG, K. J., KINJO, T. G., SZERENCSEI, R. T., ALTIMIMI, H. F., PRATIKHYA, P., WINKFEIN, R. J., SCHNETKAMP, P. P. M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
calcium homeostasis
DNA, Complementary
Fluorescence
Humans
Models, Molecular
Molecular Sequence Data
Na+/Ca2+ exchange
NCKX
photoreceptors
secondary transporters
Sequence Homology, Amino Acid
SLC24
Sodium-Calcium Exchanger - chemistry
Sodium-Calcium Exchanger - genetics
Sodium-Calcium Exchanger - physiology
Structure-Activity Relationship
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Summary::  K+‐dependent Na+/Ca2+ exchangers (NCKX) have been shown to play important roles in physiological processes as diverse as phototransduction in rod photoreceptors, motor learning and memory in mice, and skin pigmentation in humans. Most structure–function studies on NCKX proteins have been carried out on the NCKX2 isoform, but sequence similarity suggests that the results obtained with the NCKX2 isoform are likely to apply to all NCKX1‐5 members of the human SLC24 gene family. Here we review our recent work on the NCKX2 protein concerning the topological arrangement of transmembrane segments carrying out cation transport, and concerning residues important for transport function and cation binding.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1387.054