Optimized cutoffs improve performance of the aspartate aminotransferase to platelet ratio index for predicting significant liver fibrosis in human immunodeficiency virus/hepatitis C virus co-infection

Aim: To assess the diagnostic value of modified cutoffs for aspartate aminotransferase to platelet ratio index (APRI) to predict significant liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) patients. Patients and Methods: This retrospective cross‐sectional study included...

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Bibliographic Details
Published in:Liver international 2008-04, Vol.28 (4), p.486-493
Main Authors: Carvalho-Filho, Roberto J., Schiavon, Leonardo L., Narciso-Schiavon, Janaína L., Sampaio, Juliana P., Lanzoni, Valéria P., Ferraz, Maria Lucia G., Silva, Antonio Eduardo B.
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - diagnosis
Aspartate Aminotransferases - analysis
Aspartate Aminotransferases - metabolism
Biomarkers - metabolism
co-infection
Cross-Sectional Studies
Disease Progression
Female
fibrosis markers
Follow-Up Studies
hepatitis C
Hepatitis C, Chronic - complications
Hepatitis C, Chronic - diagnosis
HIV
Humans
Liver Cirrhosis - diagnosis
Liver Cirrhosis - etiology
liver fibrosis
Liver Function Tests
Male
Middle Aged
Platelet Count
Predictive Value of Tests
Probability
Retrospective Studies
Risk Assessment
ROC Curve
Sensitivity and Specificity
Severity of Illness Index
Statistics, Nonparametric
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Summary:Aim: To assess the diagnostic value of modified cutoffs for aspartate aminotransferase to platelet ratio index (APRI) to predict significant liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) patients. Patients and Methods: This retrospective cross‐sectional study included consecutive patients with HIV/HCV co‐infection who underwent percutaneous liver biopsy. The accuracy of APRI for the diagnosis of significant fibrosis (F2/F3/F4 METAVIR) was evaluated by estimating the positive and negative predictive values (PPV and NPV respectively) and by measuring the area under the receiver operating characteristics curve (AUROC). Results: One hundred and eleven patients were included (73% men, mean age 40.2±7.8 years). Significant fibrosis was observed in 45 patients (41%). To discriminate these subjects, the AUROC of APRI was 0.774±0.045. An APRI≥1.8 showed a PPV of 75% for the presence of significant fibrosis, and an index
ISSN:1478-3223
1478-3231
DOI:10.1111/j.1478-3231.2008.01675.x