Mechanisms Underlying Caloric Restriction and Lifespan Regulation: Implications for Vascular Aging

This review focuses on the emerging evidence that attenuation of the production of reactive oxygen species and inhibition of inflammatory pathways play a central role in the antiaging cardiovascular effects of caloric restriction. Particular emphasis is placed on the potential role of the plasma mem...

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Bibliographic Details
Published in:Circulation research 2008-03, Vol.102 (5), p.519-528
Main Authors: Ungvari, Zoltan, Parrado-Fernandez, Cristina, Csiszar, Anna, de Cabo, Rafael
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Biological and medical sciences
Caloric Restriction
Cardiovascular System - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Life Expectancy
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
Signal Transduction - physiology
Vertebrates: cardiovascular system
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Summary:This review focuses on the emerging evidence that attenuation of the production of reactive oxygen species and inhibition of inflammatory pathways play a central role in the antiaging cardiovascular effects of caloric restriction. Particular emphasis is placed on the potential role of the plasma membrane redox system in caloric restriction–induced pathways responsible for sensing oxidative stress and increasing cellular oxidative stress resistance. We propose that caloric restriction increases bioavailability of NO, decreases vascular reactive oxygen species generation, activates the Nrf2/antioxidant response element pathway, inducing reactive oxygen species detoxification systems, exerts antiinflammatory effects, and, thereby, suppresses initiation/progression of vascular disease that accompany aging.
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.107.168369