Caloric restrictions affect some factors involved in age-related hypercholesterolemia

Ageing has been defined as a progressive decrease in physiological capacity and a reduced ability to respond to environmental stresses. It has been observed that diet‐restricted animals show a minor morbidity in age‐related disease. Among these age‐related diseases, hypercholesterolemia is the most...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2007-05, Vol.101 (1), p.235-243
Main Authors: Martini, Chiara, Pallottini, Valentina, Cavallini, Gabriella, Donati, Alessio, Bergamini, Ettore, Trentalance, Anna
Format: Article
Language:English
Subjects:
ageing
Aging - physiology
Animals
Caloric Restriction
cholesterol
Cholesterol - blood
Gene Expression Regulation
HMG-CoA reductase
Hydroxymethylglutaryl CoA Reductases - genetics
Hydroxymethylglutaryl CoA Reductases - metabolism
Hypercholesterolemia - genetics
Hypercholesterolemia - metabolism
Insig
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
LDLr
Liver - metabolism
Male
Membrane Proteins - genetics
Membrane Proteins - metabolism
Random Allocation
rat liver
Rats
Rats, Sprague-Dawley
Receptors, LDL - genetics
Receptors, LDL - metabolism
SREBPs
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Summary:Ageing has been defined as a progressive decrease in physiological capacity and a reduced ability to respond to environmental stresses. It has been observed that diet‐restricted animals show a minor morbidity in age‐related disease. Among these age‐related diseases, hypercholesterolemia is the most recurring one and it is often associated with cardiac failure. Several studies have been published indicating age‐dependent changes in circulating levels of cholesterol in both humans and in rodents; recently changes have also been reported in the proteins involved in cholesterol homeostasis, that is, 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMG‐CoAR), Insig‐induced gene (Insig) protein, SREBP cleavage activating protein (SCAP), sterol regulatory element binding protein (SREBP), and low density lipoprotein receptor (LDLr). Most age‐related modifications of biochemical parameters are normalized or very improved in food‐restricted animals, so the aim of this work is to examine whether or not alterations of the factors involved in cholesterol homeostasis which occur during ageing could be counteracted by caloric restriction (CR). The data show that the diet restrictions used attenuate the age‐related effects on the factors involved in the synthesis and the degradation rate of HMG‐CoAR; in spite of this, CRs have a good effect on the age‐related hypercholesterolemia whose reduction seems to depend both on the correct membrane LDLr localization and on the proper restored HMG‐CoAR activity. J. Cell. Biochem. 101: 235–243, 2007. © 2007 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.21158