Association of canine obesity with reduced serum levels of C-reactive protein

Correspondence: 1 Corresponding Author: Angela P.M. Veiga, Université de Montréal–CRRA, Faculté de Médicine Vétérinaire, 3200 Rue Sicotte, Saint-Hyacinthe, Quebec, Canada J2S 7C6, e-mail: angelavet{at}terra.com.br The prevalence of obesity is increasing in dogs as well as in humans. C-reactive prote...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2008-03, Vol.20 (2), p.224-228
Main Authors: Veiga, A.P.M, Price, C.A, De Oliveira, S.T, Santos, A.P. dos, Campos, R, Barbosa, P.R, Gonzalez, F.H.D
Format: Article
Language:English
Subjects:
Animals
blood chemistry
blood glucose
Blood Glucose - metabolism
blood lipids
C-reactive protein
C-Reactive Protein - metabolism
cholesterol
Cholesterol - blood
disease prevalence
Dog Diseases - blood
Dogs
fructosamine
Fructosamine - blood
inflammation
insulin
Insulin - blood
Insulin Resistance
obesity
Obesity - blood
Obesity - veterinary
overweight
pets
Statistics, Nonparametric
triacylglycerols
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Correspondence: 1 Corresponding Author: Angela P.M. Veiga, Université de Montréal–CRRA, Faculté de Médicine Vétérinaire, 3200 Rue Sicotte, Saint-Hyacinthe, Quebec, Canada J2S 7C6, e-mail: angelavet{at}terra.com.br The prevalence of obesity is increasing in dogs as well as in humans. C-reactive protein (CRP) is an important tool for the detection of inflammation and/or early tissue damage and is linked to obesity in humans. The objective of the present study was to determine if serum CRP levels are altered in obese dogs. Fifteen lean (control group) and 16 overweight (obese group) dogs were examined. Blood samples were collected under fasted conditions for serum determination of CRP, glucose, insulin, cholesterol, triglyceride, and fructosamine. Results indicated that obese dogs were insulin resistant because serum insulin and insulin/glucose ratios were higher than in lean dogs ( P 0.05). Serum CRP concentrations were lower in obese dogs than in controls ( P 0.001). C-reactive protein was negatively correlated with insulin/glucose ratio ( R = –0.42) and cholesterol ( R = –0.39; P 0.05). Furthermore, levels of cholesterol, triglycerides, and fructosamine were increased in the obese group compared with the control group. Based on these results, it can be postulated that CRP production is inhibited by obesity and insulin resistance in dogs. Key Words: Acute phase proteins • dogs • insulin resistance
ISSN:1040-6387
1943-4936
DOI:10.1177/104063870802000214