Anti-inflammatory and antinociceptive properties of blueberry extract (Vaccinium corymbosum)

Blueberries are among the edible fruits that are recognized best for their potential health benefits. The crude extract from Vaccinium corymbosum was assessed in anti‐inflammatory and antinociceptive models. The crude hydroalcoholic extract was administered orally at doses of 100, 200 or 300 mg kg−1...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2007-04, Vol.59 (4), p.591-596
Main Authors: Torri, Eliane, Lemos, Marivane, Caliari, Vinícius, Kassuya, Cândida A. L., Bastos, Jairo K., Andrade, Sérgio F.
Format: Article
Language:English
Subjects:
Abdomen
Analgesics - administration & dosage
Analgesics - pharmacology
Animals
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Carrageenan
Constriction, Pathologic - chemically induced
Constriction, Pathologic - drug therapy
Dexamethasone - pharmacology
Dose-Response Relationship, Drug
Edema - chemically induced
Edema - drug therapy
Fruit
Granuloma, Foreign-Body - drug therapy
Histamine - physiology
Indomethacin - pharmacology
Male
Pain Measurement
Peroxidase - drug effects
Peroxidase - metabolism
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Rats
Rats, Wistar
Vaccinium
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Summary:Blueberries are among the edible fruits that are recognized best for their potential health benefits. The crude extract from Vaccinium corymbosum was assessed in anti‐inflammatory and antinociceptive models. The crude hydroalcoholic extract was administered orally at doses of 100, 200 or 300 mg kg−1 for all the assays. In the carrageenan test, the crude extract reduced rat paw oedema by 9.8, 28.5 and 65.9%, respectively. For the histamine assay, the reductions of oedema were 70.1, 71.7 and 81.9%, respectively. In the myeloperoxidase (MPO) assay, 300 mg kg−1 crude extract produced a significant inhibition of the MPO activity, at 6 h and 24 h after injection of carrageenan, by 42.8 and 46.2%, respectively. With the granulomatous tissue assay dexamethasone displayed significant activity, whereas the blueberry extract was inactive. For the abdominal constriction test, inhibitions of 49.0, 54.5, 53.5%, respectively, were observed for the crude extract, and 61.4% for indometacin. In the formalin test, the crude extract (200 and 300 mg kg−1) and indometacin inhibited only the second phase by 36.2, 35.3 and 45.8%, respectively. Considering that the crude extract of blueberry displayed antinociceptive and anti‐inflammatory activity, its consumption may be helpful for the treatment of inflammatory disorders.
ISSN:0022-3573
2042-7158
DOI:10.1211/jpp.59.4.0015