A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization

:  This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated...

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Published in:The breast journal 2008-03, Vol.14 (2), p.153-157
Main Authors: Hughes, Jenevieve H., Mason, Mark C., Gray, Richard J., McLaughlin, Sarah A., Degnim, Amy C., Fulmer, Jack T., Pockaj, Barbara A., Karstaedt, Patricia J., Roarke, Michael C.
Format: Article
Language:English
Subjects:
Biopsy - methods
Breast - pathology
breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - surgery
Female
Humans
Iodine Radioisotopes
Mammography
Mastectomy, Segmental - methods
Middle Aged
nonpalpable
radioactive seed localization
Radionuclide Imaging
Reoperation
wire localization
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cited_by cdi_FETCH-LOGICAL-c4046-2f2ff9ca09859bef59b7b42277cca73ff0296aa7f85e78d618d2fce1607c6683
cites cdi_FETCH-LOGICAL-c4046-2f2ff9ca09859bef59b7b42277cca73ff0296aa7f85e78d618d2fce1607c6683
container_end_page 157
container_issue 2
container_start_page 153
container_title The breast journal
container_volume 14
creator Hughes, Jenevieve H.
Mason, Mark C.
Gray, Richard J.
McLaughlin, Sarah A.
Degnim, Amy C.
Fulmer, Jack T.
Pockaj, Barbara A.
Karstaedt, Patricia J.
Roarke, Michael C.
description :  This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p 
doi_str_mv 10.1111/j.1524-4741.2007.00546.x
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Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p &lt; 0.001). A second operation was required in 8% of RSL patients to achieve negative margins, versus 25% of WL patients (p &lt; 0.001). Pain scores were not statistically different. However, the RSL group had higher convenience scores (p = 0.015). RSL is safe, effective, and compared to WL, reduces the rates of intraoperative re‐excision and reoperation for positive margins by 68%. Patient satisfaction is improved with RSL. We strongly favor RSL over WL.</description><subject>Biopsy - methods</subject><subject>Breast - pathology</subject><subject>breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Iodine Radioisotopes</subject><subject>Mammography</subject><subject>Mastectomy, Segmental - methods</subject><subject>Middle Aged</subject><subject>nonpalpable</subject><subject>radioactive seed localization</subject><subject>Radionuclide Imaging</subject><subject>Reoperation</subject><subject>wire localization</subject><issn>1075-122X</issn><issn>1524-4741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkE1P4zAQhi3Eiu-_gHzilmA7ju1IXAraBVbla1st3CzXGUsuaQN2ulv49bikAnHDB3skP-_M6EEIU5LTdI6nOS0Zz7jkNGeEyJyQkot8uYF2Pj42U01kmVHGHrbRboxTQgirCN9C21QxrkrBdhAM8NWi6XwWfQf4r2l8bTrfzvE4eNPg1uE_pvatsZ3_B3gEUONhaxP22mMmYjPHg6aDMDfvTNfiex_gC7aPfjjTRDhYv3to_Ovn-OwiG96cX54NhpnlhIuMOeZcZQ2pVFlNwKVLTjhjUlprZOFc2l8YI50qQapaUFUzZ4EKIq0QqthDR33bp9A-LyB2euajhaYxc2gXUUtSJIrJBKoetKGNMYDTT8HPTHjRlOiVYT3VK5F6JVKvDOt3w3qZoofrGYvJDOrP4FppAk564L9v4OXbjfX49HcqUjzr4z52sPyIm_CohSxkqe-vz_Xd7YhVV2qkq-INaOuZYg</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Hughes, Jenevieve H.</creator><creator>Mason, Mark C.</creator><creator>Gray, Richard J.</creator><creator>McLaughlin, Sarah A.</creator><creator>Degnim, Amy C.</creator><creator>Fulmer, Jack T.</creator><creator>Pockaj, Barbara A.</creator><creator>Karstaedt, Patricia J.</creator><creator>Roarke, Michael C.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization</title><author>Hughes, Jenevieve H. ; 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We strongly favor RSL over WL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18248562</pmid><doi>10.1111/j.1524-4741.2007.00546.x</doi><tpages>5</tpages></addata></record>
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source Wiley-Blackwell Journals
subjects Biopsy - methods
Breast - pathology
breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - surgery
Female
Humans
Iodine Radioisotopes
Mammography
Mastectomy, Segmental - methods
Middle Aged
nonpalpable
radioactive seed localization
Radionuclide Imaging
Reoperation
wire localization
title A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization
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