A Multi-site Validation Trial of Radioactive Seed Localization as an Alternative to Wire Localization

:  This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated...

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Bibliographic Details
Published in:The breast journal 2008-03, Vol.14 (2), p.153-157
Main Authors: Hughes, Jenevieve H., Mason, Mark C., Gray, Richard J., McLaughlin, Sarah A., Degnim, Amy C., Fulmer, Jack T., Pockaj, Barbara A., Karstaedt, Patricia J., Roarke, Michael C.
Format: Article
Language:English
Subjects:
Biopsy - methods
Breast - pathology
breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - surgery
Female
Humans
Iodine Radioisotopes
Mammography
Mastectomy, Segmental - methods
Middle Aged
nonpalpable
radioactive seed localization
Radionuclide Imaging
Reoperation
wire localization
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Summary::  This study aims to validate radioactive seed localization (RSL) as an alternative to wire localization (WL) in the operative excision of nonpalpable breast lesions. Eligible patients were recruited sequentially. A sample of 99 patients treated with WL was compared to the next 383 patients treated with RSL. Margins were considered “negative” if ≥2 mm from in‐situ and invasive disease. Pain and convenience scores were recorded on a 10‐point scale. Patient characteristics and histology were similar. The lesion and localization device were retrieved in all patients. Margins of the first specimen were negative in 73% of RSL patients, versus 54% of WL patients (p 
ISSN:1075-122X
1524-4741
DOI:10.1111/j.1524-4741.2007.00546.x