Protection against Oxidative Stress in Diabetic Rats by Wheat Bran Feruloyl Oligosaccharides

Diabetes is one of the most costly of the chronic diseases and is increasing in epidemic proportions in developing countries. It has been found that some antioxidants play a role in protection against oxidative stress, which is associated with diabetes. In this study, enzyme-released feruloyl oligos...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2007-04, Vol.55 (8), p.3191-3195
Main Authors: Ou, Shi-Yi, Jackson, G. Michael, Jiao, Xia, Chen, Jing, Wu, Jian-Zhong, Huang, Xue-Song
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
antioxidants
Biological and medical sciences
blood glucose
blood serum
Cereal and baking product industries
Coumaric Acids - administration & dosage
diabetes
Diabetes Mellitus, Experimental - therapy
Diet
Dietary Fiber - analysis
enzyme activity
feruloyl oligosaccharides
Food industries
food intake
Fundamental and applied biological sciences. Psychology
glutathione peroxidase
liver
Male
oligosaccharides
Oligosaccharides - administration & dosage
oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Sprague-Dawley
superoxide dismutase
testes
wheat bran
xanthine oxidase
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Summary:Diabetes is one of the most costly of the chronic diseases and is increasing in epidemic proportions in developing countries. It has been found that some antioxidants play a role in protection against oxidative stress, which is associated with diabetes. In this study, enzyme-released feruloyl oligosaccharides from wheat bran were given intragastrically (ig) to test their effect on antioxidant capacity, body weight restoring capacity, and serum glucose level in alloxan-induced diabetic Sprague−Dawley (SD) rats, using sodium ferulate and vitamin C as positive control groups. The levels of blood glucose, total antioxidant capacity (TAOC), and malondiadehyde (MDA) and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XOD) were determined in rat serum, liver, and testes. Feruloyl oligosaccharides significantly increased TAOC level, GSH-Px, and SOD activities, but decreased blood glucose and MDA levels and XOD activity in serum, liver, and testes of diabetic rats compared to diabetic controls. Feruloyl oligosaccharides were, overall, more efficient in mitigating oxidative damage in diabetic rats than sodium ferulate and vitamin C. In this feruloyl oligosaccharide feeding study, the antioxidant restoring capacity varied across the tissues observed, and also the activity change of the various antioxidant enzymes varied within a single tissue. Feruloyl oligosaccharides showed greater antioxidant capacity in vivo than in vitro when compared with vitamin C. Keywords: Feruloyl oligosaccharides; wheat bran; diabetes; oxidative stress, total antioxidant activity (TOAC); alloxan
ISSN:0021-8561
1520-5118
DOI:10.1021/jf063310v