Comparison of taurine chloramine and taurine bromamine effects on rheumatoid arthritis synoviocytes

Fibroblast-like synoviocytes (FLS) participate in rheumatoid arthritis (RA) chronic synovitis by producing pro-inflammatory cytokines (IL-6, IL-8), growth factors (VEGF) and other inflammatory mediators (PGE₂, NO). We have previously reported that Tau-Cl, generated by neutrophils, inhibits in vitro...

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Bibliographic Details
Published in:Amino acids 2007-04, Vol.32 (3), p.447-452
Main Authors: Kontny, E, Chorąży-Massalska, M, Rudnicka, W, Marcinkiewicz, J, Maśliński, W
Format: Article
Language:English
Subjects:
Amino acids
Arthritis
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Cytokines
Dose-Response Relationship, Drug
Enzyme Inhibitors - metabolism
Enzyme Inhibitors - pharmacology
Eosinophils
Eosinophils - metabolism
Eosinophils - pathology
Female
Fibroblasts - metabolism
Fibroblasts - pathology
Growth factors
Humans
In vitro testing
inflammation
Inflammation Mediators - metabolism
Male
Medical research
Middle Aged
Neutrophils - metabolism
Neutrophils - pathology
Rheumatoid arthritis
Synovial Membrane - metabolism
Synovial Membrane - pathology
Synoviocytes
Synthesis
Taurine - analogs & derivatives
Taurine - metabolism
Taurine - pharmacology
Taurine bromamine
Taurine chloramine
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Summary:Fibroblast-like synoviocytes (FLS) participate in rheumatoid arthritis (RA) chronic synovitis by producing pro-inflammatory cytokines (IL-6, IL-8), growth factors (VEGF) and other inflammatory mediators (PGE₂, NO). We have previously reported that Tau-Cl, generated by neutrophils, inhibits in vitro some of these pathogenic RA FLS functions. Taurine bromamine (Tau-Br) originates from eosinophils and neutrophils, and its immunoregulatory activities are poorly known. Therefore, we investigated the effects of Tau-Br on RA FLS functions and compared it to Tau-Cl anti-inflammatory action. When applied at noncytotoxic concentrations: (i) Tau-Br inhibited IL-6 and PGE₂ production with potency similar to Tau-Cl (IC₅₀ [almost equal to] 250 μM), (ii) Tau-Br failed to affect VEGF and IL-8 synthesis, while Tau-Cl exerted inhibitory effect (IC₅₀ [almost equal to] 400 μM), (iii) none of these compounds affected NO generation and iNOS expression. Thus, Tau-Cl is more effective than Tau-Br in normalization of pro-inflammatory RA FLS functions.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-006-0368-0