Specific antibody detection in serum, urine and saliva samples for the diagnosis of cystic echinococcosis

Serum, saliva and urine samples of 25 clinically and radiologically diagnosed cystic echinoccosis (CE) patients, 25 clinically suspected cases of CE, 15 other parasitic disease controls and 25 healthy controls were evaluated for anti-hydatid antibody response by ELISA. The sensitivity of serum, sali...

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Bibliographic Details
Published in:Acta tropica 2007-03, Vol.101 (3), p.187-191
Main Authors: Sunita, T., Dubey, M.L., Khurana, Sumeeta, Malla, Nancy
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antibodies, Helminth - blood
Antibodies, Helminth - isolation & purification
Antibodies, Helminth - urine
Biological and medical sciences
Case-Control Studies
Child
Cystic echinoccosis
Diagnosis, Differential
Diseases caused by cestodes
Echinococcoses
Echinococcosis - blood
Echinococcosis - diagnosis
Echinococcosis - immunology
Echinococcus granulosus - immunology
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Helminthic diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Parasitic diseases
Parasitic Diseases - blood
Parasitic Diseases - diagnosis
Parasitic Diseases - urine
Saliva
Saliva - parasitology
Serodiagnosis
Urine
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Description
Summary:Serum, saliva and urine samples of 25 clinically and radiologically diagnosed cystic echinoccosis (CE) patients, 25 clinically suspected cases of CE, 15 other parasitic disease controls and 25 healthy controls were evaluated for anti-hydatid antibody response by ELISA. The sensitivity of serum, saliva and urine was found to be 72, 56 and 84%, respectively, while specificity was 76% in all the samples. Urine showed significantly higher ( p < 0.05) sensitivity than that of saliva samples but not significantly higher ( p > 0.05) than that of serum samples. There was no significant difference in the immune response of patients with hepatic versus extrahepatic cysts and single versus multiple cysts. Thus, biological fluid like urine may be used as an alternative or as an adjunct to serum samples by virtue of its non-invasive, easy collection and similar sensitivity and specificity.
ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2006.07.014