Assessment of Changes in Non-Calcified Atherosclerotic Plaque Volume in the Left Main and Left Anterior Descending Coronary Arteries over Time by 64-Slice Computed Tomography

Multidetector computed tomography (MDCT) permits the visualization of the coronary arteries and of coronary atherosclerotic plaques. The natural course of noncalcified plaque is not known. This study was conducted to measure the change in noncalcified coronary plaque volume in the left main coronary...

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Bibliographic Details
Published in:The American journal of cardiology 2008-03, Vol.101 (5), p.579-584
Main Authors: Schmid, Michael, MD, Achenbach, Stephan, MD, Ropers, Dieter, MD, Komatsu, Sei, MD, Ropers, Ulrike, MD, Daniel, Werner G., MD, Pflederer, Tobias, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Calcium
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cholesterol, LDL - blood
Contrast Media - administration & dosage
Coronary Angiography - methods
Coronary Artery Disease - diagnostic imaging
Coronary vessels
Disease Progression
Female
Follow-Up Studies
Humans
Iohexol - administration & dosage
Iohexol - analogs & derivatives
Male
Medical sciences
Middle Aged
Retrospective Studies
Tomography
Tomography, X-Ray Computed - methods
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Summary:Multidetector computed tomography (MDCT) permits the visualization of the coronary arteries and of coronary atherosclerotic plaques. The natural course of noncalcified plaque is not known. This study was conducted to measure the change in noncalcified coronary plaque volume in the left main coronary artery and in the proximal left anterior descending coronary artery over time using 64-slice MDCT. Fifty patients in whom noncalcified lesions had been detected on baseline MDCT received follow-up scans after an interval of 17 ± 6 months. Plaque areas were traced manually in serial multiplanar reconstructions to determine overall volume. The mean plaque volumes were 92 ± 81 mm3 on baseline MDCT and 115 ± 110 mm3 on follow-up MDCT (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2007.10.016