Maternal C-reactive protein and developmental programming of atherosclerosis

Objective Maternal hypercholesterolemia during pregnancy enhances the susceptibility to atherosclerosis in their offspring by oxidation-dependent mechanisms. The present study investigated whether maternal C-reactive protein (CRP) level, which is an indicator of inflammation and cardiovascular risk,...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2008-03, Vol.198 (3), p.281.e1-281.e5
Main Authors: Liguori, Antonio, MD, D’Armiento, Francesco P., MD, Palagiano, Antonio, MD, Palinski, Wulf, MD, Napoli, Claudio, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Atherosclerosis - embryology
Atherosclerosis - epidemiology
Biological and medical sciences
Blood and lymphatic vessels
C-Reactive Protein - analysis
C-Reactive Protein - physiology
Cardiology. Vascular system
Child
Child, Preschool
CRP
developmental programming
Female
Gynecology. Andrology. Obstetrics
Humans
Hypercholesterolemia - blood
Infant
inflammation
maternal hypercholesterolemia
Medical sciences
Obstetrics and Gynecology
oxidative stress
Pregnancy
Pregnancy Complications - blood
Smoking - adverse effects
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Summary:Objective Maternal hypercholesterolemia during pregnancy enhances the susceptibility to atherosclerosis in their offspring by oxidation-dependent mechanisms. The present study investigated whether maternal C-reactive protein (CRP) level, which is an indicator of inflammation and cardiovascular risk, or smoking, which enhances oxidative stress, predict the in utero programming of atherosclerosis. Study Design Subsets of patients from the Fate of Early Lesions in Childhood study (156 normocholesterolemic children) were examined at autopsy, classified by maternal cholesterol levels during pregnancy. Maternal CRP level was correlated with maternal cholesterol and aortic atherosclerosis of children. Results CRP level was elevated in hypercholesterolemic mothers and showed significant correlation with atherogenesis in children in univariate and multivariate analysis. However, many hypercholesterolemic mothers did not have elevated CRP levels. Smoking only correlated in univariate analysis. Conclusion CRP level during pregnancy is a predictor of increased atherogenesis in children of hypercholesterolemic mothers, albeit a weaker one than maternal cholesterol. In the presence of hypercholesterolemia, maternal smoking does not further enhance atherogenic programming.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.11.027