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A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth
Temporal control can be considered the fourth dimension in embryonic development. The identification of the somitogenesis molecular clock provided new insight into how embryonic cells measure time. We provide the first evidence of a molecular clock operating during chick fore-limb autopod outgrowth...
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| Published in: | Journal of molecular biology 2007-04, Vol.368 (2), p.303-309 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c448t-3a13b8fba9a156c7f2faa070d4862bd6db6e96a6fdb76f0136c386dea9762c623 |
| container_end_page | 309 |
| container_issue | 2 |
| container_start_page | 303 |
| container_title | Journal of molecular biology |
| container_volume | 368 |
| creator | Pascoal, Susana Carvalho, Cláudia R. Rodriguez-León, Joaquín Delfini, Marie-Claire Duprez, Delphine Thorsteinsdóttir, Sólveig Palmeirim, Isabel |
| description | Temporal control can be considered the fourth dimension in embryonic development. The identification of the somitogenesis molecular clock provided new insight into how embryonic cells measure time. We provide the first evidence of a molecular clock operating during chick fore-limb autopod outgrowth and patterning, by showing that the expression of the somitogenesis clock component
hairy2 cycles in autopod chondrogenic precursor cells with a 6 h periodicity. We determined the length of time required to form an autopod skeletal limb element, and established a correlation between the latter and the periodicity of cyclic
hairy2 gene expression. We suggest that temporal control exerted by cyclic gene expression can be a widespread mechanism providing cellular temporal information during vertebrate embryonic development. |
| doi_str_mv | 10.1016/j.jmb.2007.01.089 |
| format | article |
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hairy2 cycles in autopod chondrogenic precursor cells with a 6 h periodicity. We determined the length of time required to form an autopod skeletal limb element, and established a correlation between the latter and the periodicity of cyclic
hairy2 gene expression. We suggest that temporal control exerted by cyclic gene expression can be a widespread mechanism providing cellular temporal information during vertebrate embryonic development.</description><identifier>ISSN: 0022-2836</identifier><identifier>EISSN: 1089-8638</identifier><identifier>DOI: 10.1016/j.jmb.2007.01.089</identifier><identifier>PMID: 17346744</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Avian Proteins - genetics ; Avian Proteins - metabolism ; Biological Clocks ; Body Patterning ; Chick Embryo ; cycling genes ; Embryonic Development ; Forelimb - embryology ; Gene Expression Regulation, Developmental ; hairy2 ; limb development ; Mesoderm - metabolism ; molecular clock ; Periodicity ; vertebrate embryo</subject><ispartof>Journal of molecular biology, 2007-04, Vol.368 (2), p.303-309</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-3a13b8fba9a156c7f2faa070d4862bd6db6e96a6fdb76f0136c386dea9762c623</citedby><cites>FETCH-LOGICAL-c448t-3a13b8fba9a156c7f2faa070d4862bd6db6e96a6fdb76f0136c386dea9762c623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17346744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pascoal, Susana</creatorcontrib><creatorcontrib>Carvalho, Cláudia R.</creatorcontrib><creatorcontrib>Rodriguez-León, Joaquín</creatorcontrib><creatorcontrib>Delfini, Marie-Claire</creatorcontrib><creatorcontrib>Duprez, Delphine</creatorcontrib><creatorcontrib>Thorsteinsdóttir, Sólveig</creatorcontrib><creatorcontrib>Palmeirim, Isabel</creatorcontrib><title>A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth</title><title>Journal of molecular biology</title><addtitle>J Mol Biol</addtitle><description>Temporal control can be considered the fourth dimension in embryonic development. The identification of the somitogenesis molecular clock provided new insight into how embryonic cells measure time. We provide the first evidence of a molecular clock operating during chick fore-limb autopod outgrowth and patterning, by showing that the expression of the somitogenesis clock component
hairy2 cycles in autopod chondrogenic precursor cells with a 6 h periodicity. We determined the length of time required to form an autopod skeletal limb element, and established a correlation between the latter and the periodicity of cyclic
hairy2 gene expression. We suggest that temporal control exerted by cyclic gene expression can be a widespread mechanism providing cellular temporal information during vertebrate embryonic development.</description><subject>Animals</subject><subject>Avian Proteins - genetics</subject><subject>Avian Proteins - metabolism</subject><subject>Biological Clocks</subject><subject>Body Patterning</subject><subject>Chick Embryo</subject><subject>cycling genes</subject><subject>Embryonic Development</subject><subject>Forelimb - embryology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>hairy2</subject><subject>limb development</subject><subject>Mesoderm - metabolism</subject><subject>molecular clock</subject><subject>Periodicity</subject><subject>vertebrate embryo</subject><issn>0022-2836</issn><issn>1089-8638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEUhYMotlZ_gBuZlbsZb5JpkuKq1FdBqQtdh0ySaVOnTU1mfPx7U1pwp6sDl-8cuB9C5xgKDJhdLYvlqioIAC8AFyBGB6iPU-SCUXGI-gCE5ERQ1kMnMS4BYEhLcYx6mNOS8bLso-k4e_KN1V2jQjZpvH7LZhsbVGtjdtMFt55nk4VL13HX-o032XPwX26lmty42Komm3XtPPjPdnGKjmrVRHu2zwF6vbt9mTzkj7P76WT8mOuyFG1OFaaVqCs1UnjINK9JrRRwMKVgpDLMVMyOmGK1qTirAVOmqWDGqhFnRDNCB-hyt7sJ_r2zsZUrF7VtGrW2vouSA6UsPfgvSIBjUVKRQLwDdfAxBlvLTUgvhm-JQW5Fy6VMouVWtAQsk-HUudiPd9XKmt_G3mwCrneATS4-nA0yamfX2hoXrG6l8e6P-R-nXY32</recordid><startdate>20070427</startdate><enddate>20070427</enddate><creator>Pascoal, Susana</creator><creator>Carvalho, Cláudia R.</creator><creator>Rodriguez-León, Joaquín</creator><creator>Delfini, Marie-Claire</creator><creator>Duprez, Delphine</creator><creator>Thorsteinsdóttir, Sólveig</creator><creator>Palmeirim, Isabel</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20070427</creationdate><title>A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth</title><author>Pascoal, Susana ; Carvalho, Cláudia R. ; Rodriguez-León, Joaquín ; Delfini, Marie-Claire ; Duprez, Delphine ; Thorsteinsdóttir, Sólveig ; Palmeirim, Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-3a13b8fba9a156c7f2faa070d4862bd6db6e96a6fdb76f0136c386dea9762c623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Avian Proteins - genetics</topic><topic>Avian Proteins - metabolism</topic><topic>Biological Clocks</topic><topic>Body Patterning</topic><topic>Chick Embryo</topic><topic>cycling genes</topic><topic>Embryonic Development</topic><topic>Forelimb - embryology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>hairy2</topic><topic>limb development</topic><topic>Mesoderm - metabolism</topic><topic>molecular clock</topic><topic>Periodicity</topic><topic>vertebrate embryo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pascoal, Susana</creatorcontrib><creatorcontrib>Carvalho, Cláudia R.</creatorcontrib><creatorcontrib>Rodriguez-León, Joaquín</creatorcontrib><creatorcontrib>Delfini, Marie-Claire</creatorcontrib><creatorcontrib>Duprez, Delphine</creatorcontrib><creatorcontrib>Thorsteinsdóttir, Sólveig</creatorcontrib><creatorcontrib>Palmeirim, Isabel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascoal, Susana</au><au>Carvalho, Cláudia R.</au><au>Rodriguez-León, Joaquín</au><au>Delfini, Marie-Claire</au><au>Duprez, Delphine</au><au>Thorsteinsdóttir, Sólveig</au><au>Palmeirim, Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth</atitle><jtitle>Journal of molecular biology</jtitle><addtitle>J Mol Biol</addtitle><date>2007-04-27</date><risdate>2007</risdate><volume>368</volume><issue>2</issue><spage>303</spage><epage>309</epage><pages>303-309</pages><issn>0022-2836</issn><eissn>1089-8638</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Temporal control can be considered the fourth dimension in embryonic development. 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hairy2 cycles in autopod chondrogenic precursor cells with a 6 h periodicity. We determined the length of time required to form an autopod skeletal limb element, and established a correlation between the latter and the periodicity of cyclic
hairy2 gene expression. We suggest that temporal control exerted by cyclic gene expression can be a widespread mechanism providing cellular temporal information during vertebrate embryonic development.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17346744</pmid><doi>10.1016/j.jmb.2007.01.089</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of molecular biology, 2007-04, Vol.368 (2), p.303-309 |
| issn | 0022-2836 1089-8638 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Avian Proteins - genetics Avian Proteins - metabolism Biological Clocks Body Patterning Chick Embryo cycling genes Embryonic Development Forelimb - embryology Gene Expression Regulation, Developmental hairy2 limb development Mesoderm - metabolism molecular clock Periodicity vertebrate embryo |
| title | A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth |
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