A Molecular Clock Operates During Chick Autopod Proximal-distal Outgrowth

Temporal control can be considered the fourth dimension in embryonic development. The identification of the somitogenesis molecular clock provided new insight into how embryonic cells measure time. We provide the first evidence of a molecular clock operating during chick fore-limb autopod outgrowth...

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Bibliographic Details
Published in:Journal of molecular biology 2007-04, Vol.368 (2), p.303-309
Main Authors: Pascoal, Susana, Carvalho, Cláudia R., Rodriguez-León, Joaquín, Delfini, Marie-Claire, Duprez, Delphine, Thorsteinsdóttir, Sólveig, Palmeirim, Isabel
Format: Article
Language:English
Subjects:
Animals
Avian Proteins - genetics
Avian Proteins - metabolism
Biological Clocks
Body Patterning
Chick Embryo
cycling genes
Embryonic Development
Forelimb - embryology
Gene Expression Regulation, Developmental
hairy2
limb development
Mesoderm - metabolism
molecular clock
Periodicity
vertebrate embryo
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Summary:Temporal control can be considered the fourth dimension in embryonic development. The identification of the somitogenesis molecular clock provided new insight into how embryonic cells measure time. We provide the first evidence of a molecular clock operating during chick fore-limb autopod outgrowth and patterning, by showing that the expression of the somitogenesis clock component hairy2 cycles in autopod chondrogenic precursor cells with a 6 h periodicity. We determined the length of time required to form an autopod skeletal limb element, and established a correlation between the latter and the periodicity of cyclic hairy2 gene expression. We suggest that temporal control exerted by cyclic gene expression can be a widespread mechanism providing cellular temporal information during vertebrate embryonic development.
ISSN:0022-2836
1089-8638
DOI:10.1016/j.jmb.2007.01.089